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【medical-news】激素治疗能延长卵巢癌患者的寿命
Hormone Therapy Extends Lives of Ovarian Cancer Patients
The use of letrozole may also delay need for chemotherapy, study says
By Steven Reinberg
HealthDay Reporter
FRIDAY, June 15 (HealthDay News) -- Hormone therapy that has proved successful against breast cancer may also extend and improve the lives of women with estrogen-sensitive ovarian cancer, a British study suggests.
Letrozole hormone therapy may also be an alternative to chemotherapy for some women with the disease, according the report in the June 15 issue of Clinical Cancer Research.
"This study demonstrates that some ovarian cancers are responsive to anti-estrogen hormonal therapy, and these cancers, and therefore the patients who would benefit, can be identified," said lead researcher Simon Langdon, a Cancer Research UK scientist and a senior lecturer in cancer research at the University of Edinburgh.
Langdon noted that his team's research has shown that growth of certain ovarian cancers is stimulated by the female hormone estrogen. "These cancers could be identified as those possessing high levels of the estrogen receptor," he said.
For the study, which included 44 women, the researchers used letrozole, which works by limiting production of estrogen in the body. "This treatment then effectively starves the ovarian cancer of estrogen and inhibits growth," Langdon said.
During six months of treatment, 25 percent of the women had no tumor growth, and 33 percent of the women with the greatest estrogen values had a positive response that delayed the use of chemotherapy. "Within the trial, we were able to show that tumors with the highest levels of estrogen receptor were the most likely to respond to treatment," Langdon said.
"This approach provides an addition to chemotherapy for this disease," he added. "It is unlikely to replace chemotherapy but could be used to delay the need for chemotherapy."
The patients most likely to benefit from the therapy can be identified before treatment starts. So, this kind of approach means women can be better targeted and the drug not given to those unlikely to benefit who should receive some other type of treatment, Langdon said.
The American Cancer Society reports that ovarian cancer is the eighth most common cancer in women, not including skin cancer. There will be about 22,430 new cases of ovarian cancer in the United States this year, and an estimated 15,280 women will die from the disease.
A large majority -- about two-thirds -- of women with ovarian cancer are 55 or older. A woman's risk of getting ovarian cancer is about one in 67, according to the cancer society.
Dr. Len Lichtenfeld, the deputy chief medical officer at the American Cancer Society, said, "Letrozole is already approved for treating ovarian cancer in women who have failed other treatment. This study refines these researchers' previous work by identifying those women with estrogen-receptor-sensitive ovarian cancer who are the most likely to respond to this drug.
"Whether the drug should be started earlier in the course of ovarian cancer and whether we should be evaluating whether or not a woman has estrogen-receptor-sensitive ovarian cancer are questions that need to be answered," he said. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Hormone Therapy Extends Lives of Ovarian Cancer Patients
激素治疗能延长卵巢癌患者的寿命
The use of letrozole may also delay need for chemotherapy, study says
研究表明使用来曲唑同样可以推迟化疗
By Steven Reinberg
HealthDay Reporter
FRIDAY, June 15 (HealthDay News) -- Hormone therapy that has proved successful against breast cancer may also extend and improve the lives of women with estrogen-sensitive ovarian cancer, a British study suggests.
6月15日，星期五（每日健康新闻）-英国一项研究提示，已成功用于治疗乳腺癌的激素疗法同样可以延长雌激素敏感性卵巢癌妇女的生命并可改善其生活质量。
Letrozole hormone therapy may also be an alternative to chemotherapy for some women with the disease, according the report in the June 15 issue of Clinical Cancer Research.
据6月15日出版的临床肿瘤研究报导，对于一些患卵巢癌的女性，除采用化疗外同样可以采用来曲唑激素疗法。
"This study demonstrates that some ovarian cancers are responsive to anti-estrogen hormonal therapy, and these cancers, and therefore the patients who would benefit, can be identified," said lead researcher Simon Langdon, a Cancer Research UK scientist and a senior lecturer in cancer research at the University of Edinburgh.
Simon Langdon是英国肿瘤研究的一位首席科学家，也是爱丁堡大学肿瘤研究的高级讲师。他说：“这项研究表明一些卵巢癌对抗雌激素的激素疗法敏感，因此我们应当找出能从这种疗法受益中的患者。”
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作者:admin@医学,生命科学 2011-03-11 17:11
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