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【drug-news】FDA止痛药警告：如何避免服用过多（
The FDA's Painkiller Warning: How to Avoid Taking Too Much
An overdose of Tylenol can damage the liver. The problem is, we're often taking it when we don't even realize it
By ALICE PARK
SUBSCRIBE TO TIMEPRINTE-MAILMORE BY AUTHORBackground: The Tylenol Scare
Posted Wednesday, Dec. 20, 2006
It's cold season, so you probably don't think anything of downing a dose or two of a cold medicine on top of the Tylenol you might be taking for that headache you got after muscling your way through the crowded shopping mall. Well, the Food and Drug Administration wants you to think twice about all that self-medicating you're doing with over-the-counter remedies. Every year, the agency says, about half of the deaths associated with taking painkillers containing acetaminophen are due to unintended overdoses. Acetaminophen, the primary ingredient in Tylenol, is also a common component of cold and flu remedies. The concern, says the FDA, is that people aren't aware of all the different compounds that contain acetaminophen, so when they decide to boost their dose of Tylenol, or combine a painkiller with a cold caplet or two, they could be putting their liver in danger.
An overdose of acetaminophen can damage the liver, which metabolizes and breaks down drugs. More than 200 million people take Tylenol in the U.S. each year, and about 200 a year die from liver failure when they accidentally take too much. What the FDA proposed is to require manufacturers of acetaminophen-containing over-the-counter drugs to prominently note the presence of the compound, and warn people of the danger of liver toxicity when acetaminophen is taken in excees of recommended doses.
According to Dr. Charles Cain, director of anesthesia at New York Presbyterian Hospital, it's not that hard to reach these danger levels. The average adult should not exceed 4g of acetaminophen a day. If someone is taking two extra-strength tablets of Tylenol, which are 500 mg each, every four hours (instead of the recommended every six hours), and then adds a few doses of a cold medication during the day, then they're easily reaching about 4g-6g of acetaminophen a day. Do that over a few days, says Cain, and you could damage your liver. Since most people are on several different types of medications already, the liver may be more vulnerable to danger when it's hit with an excess of acetaminophen to process. And that's even before the glass of wine or bottle of beer that many of us like to have at the end of day; alcohol also puts the liver to work, and the combination of everything at once may be the perfect storm that sends the liver into failure.
The FDA warning is an effort to educate the public, says Cain, As the number of acetaminophen-containing preparations becomes ubiquitous, the concern is that we are seeing instances where people are taking too much and wind up suffering from what should otherwise be a relatively safe medication.
At Columbia University Medical Center, doctors have been aware of the potential dangers of acetaminophen overdose and for the past two months have provided patients with brochures indicating the daily amount of acetaminophen their doctors recommend they take, and how much additional acetaminophen they can safely take from other sources. "Whenever I prescribe any medication, I always tell my patients that if they are buying drugs over the counter, to check for the label, and make sure that the medication does not contain any acetaminophen," says Dr. Amit Sharma, an anesthesiologist at the hospital. "If it does, then I tell them to cut down on the pain medication given by their doctor."
For the most part, Tylenol and acetaminophen products are safe — that's why there are offered over-the-counter and without a doctor's prescription. But the FDA wants to alert people that like any drug, taking too much — more than your liver can handle — can be dangerous. And with more people taking more medications at a younger age, being aware of potential interactions among drugs, as well as potential overdoses, is critical. These over-the-counter drugs just have to be used with an eye toward the total dose per day, and amount being used over a period of days, says Cain. When used with care, acetaminophen is extremely safe. 我认领这个,48小时没做完,拜托各位帮忙 对不起,最近事比较多,请其他战友自由认领该文,谢谢 The FDA's Painkiller Warning: How to Avoid Taking Too Much
FDA关于止痛药警告：如何避免服用过多
An overdose of Tylenol can damage the liver. The problem is, we're often taking it when we don't even realize it
过量服用对乙酰氨基酚（泰诺，Tylenol）可能损伤肝脏。但问题是，我们经常使用它却并不真正了解它。
By ALICE PARK
SUBSCRIBE TO TIMEPRINT E-MAILMORE BY AUTHOR Background: The Tylenol Scare
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作者:admin@医学,生命科学 2011-04-15 17:14
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