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【medical-news】taranabant 助您减去10%的体重
Study Shows Drug Helps People Shed Nearly 15 Pounds in a Year 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 Taranabant May Help Dieters Lose Weight
Taranabant有助于减肥者减轻体重
Study Shows Drug Helps People Shed Nearly 15 Pounds in a Year
研究表明药物可使人一年减轻近15磅
March 31, 2008 (Chicago) -- An experimental weight loss drug helped dieters shed an average of 14.5 pounds over the course of one year.
一种实验性的减肥药可使减肥者平均一年减轻14.5磅March 31, 2008 (Chicago)。
Researchers studied more than 800 overweight and obese people on a diet and exercise program; 28% of those given the drug taranabant lost more than 10% of their body weight compared with 8% of those taking placebo.
研究人员研究了800多超重和肥胖人士的饮食和运动情况；服用taranabant的减肥者中有28%的体重比服用安慰剂的8%的减肥者减轻10%。
"Even losing just 5% of your body weight is important to your health," says researcher Louis Aronne, MD, clinical professor of medicine at Weill-Cornell Medical College and director of the comprehensive weight control program at New York Presbyterian Hospital.
康奈尔医学院临床教授和纽约Presbyterian 医院综合体重控制项目主任Louis Aronne说：“即使只减轻5%对健康来说也是很重要的。”
"It will help you lower your risk factors of cardiovascular disease," he tells WebMD.
他告诉WebMD：“这将有利于降低心血管疾病的危险因素。”
The findings were presented at the 57th annual scientific session of the American College of Cardiology.
美国心脏病学会第57届年会上提出了这些研究结果。
Weight Loss Accompanied by Lower Triglycerides
体重的减轻伴随着甘油三酯水平的降低
The one-year study involved 414 patients randomly assigned to take 2 milligrams of taranabant daily and 417 patients given placebo.
一项为期一年的研究将患者随机分为两组，其中414名患者每天服用2mg taranabant，另417名患者服用安慰剂。
Results showed that patients reached their lowest weight about nine months into the study. They were then able to maintain that weight for the rest of the year, Aronne says.
9个月左右可达到最低体重的患者进入研究。Aronne说他们可在这一年的后三个月维持这个体重。
Patients taking taranabant also experienced a rise in levels of HDL"good" cholesterol and a drop in triglyceride levels.
服用taranabant的患者其HDL水平上升和甘油三酯水平下降。
The most common side effects were nausea and diarrhea, but less than 2% of patients dropped out because of these problems.
最普遍的副作用就是呕吐和腹泻，但是只有不到2%的患者因为这些副作用而退出研究。
Taranabant Helps You Resist Food Cravings
Taranabant有助于你抵制食物引诱
Taranabant is a member of the same class of drugs as Zimulti. Taranbant helps people resist food cravings by partially shutting down the cannabinoid system.
Taranabant是同类药Zimulti的一种，Taranbant有助于人们通过关闭大麻素系统而抵制食物的诱惑。
Zimulti recently failed to win approval from an FDA advisory panel, mainly because of fears that it could lead to depression and suicidal thoughts in some patients. The drug was previously known as Acomplia.
Zimulti近来由于其可能会导致患者抑郁和产生自杀的念头而失去FDA顾问小组的批准，该药以前作为Acomplia而闻名。
But at the 2-milligram dose, taranabant was not associated with an increased risk of depression or suicidal thoughts, Aronne says. People taking the drug were also no more likely to suffer from crying, tearfulness, or anxiety than those on placebo.
Aronne说2mg剂量taranabant与抑郁和自杀想法增加的风险是无关的。服用该药的患者并不比服用安慰剂的患者遭受更多的哭闹、流泪或者焦虑。
In fact, irritability was the only psychiatric symptom experienced by more patients taking the 2-milligram dose of taranabant compared with placebo, says Noreen Verbrugge, a spokesperson for Merck Research Laboratories. Merck makes taranabant and sponsored the study.
事实上，相比较服用安慰剂的患者来说，应激仅仅是服用2mg taranabant患者的精神症状。
The study also included patients given a higher dose of taranabant. But due to a high rate of side effects, only the 2-milligram dose will be studied further, she says.
研究也包括那些服用更高剂量taranabant的患者。她说由于副作用的高发率，只有2mg剂量才被进一步研究。
American Heart Association President Dan Jones, MD, dean of the University of Mississippi School of Medicine in Jackson, tells WebMD that much more study is needed. "Weight loss is highly complex," he says, and "every [drug] we have tried to attack it with has been associated with substantial side effects.
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作者:admin@医学,生命科学 2011-01-16 05:14
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