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【medical-news】研究发现罕见的致命性儿童癌症基
WASHINGTON (Reuters) - Researchers have found a gene that causes most inherited forms of neuroblastoma, a rare and deadly form of childhood cancer, and say the discovery points to new treatments.
Mutations in a gene called ALK were strongly linked to neuroblastoma, the researchers from the United States, Italy and Belgium reported on Sunday. They said several companies already are working on drugs that target this gene, which is also mutated in some cases of lung cancer and lymphoma.
"This discovery enables us to offer the first genetic tests to families affected by the inherited form of this disease," said Dr. Yael Mosse of The Children's Hospital of Philadelphia, who worked on the study.
"Furthermore, because there already are drugs in development that target the same gene in adult cancers, we can soon begin testing those drugs in children with neuroblastoma."
Neuroblastoma accounts for 15 percent of childhood cancer deaths, with just a 40 percent survival rate, even though it only causes about 7 percent of all pediatric cancers.
Writing in the journal Nature, the team at Children's Hospital, the Scripps Research Institute in La Jolla, California, and elsewhere said they studied 20 families with one or more children with neuroblastoma.
They found mutations in the ALK gene that cause it to be constantly active in helping cells proliferate. Out-of-control proliferation is the hallmark of cancer.
"This is a very important discovery, as it not only helps us understand the genetic roots of this terrible disease, but also has led to dramatically new ideas for curative therapy," said Dr. John Maris of Children's Hospital, who directed the study.
After finding the ALK mutations in familial neuroblastoma, the researchers looked at sporadic cases -- those not occurring in families with a history of the disease. They found ALK mutations in 12 percent of 194 tumor samples from children with the aggressive, high-risk form of the disease.
http://www.reuters.com/article/healthNews/idUSN2439139820080824 本人已令人另本文翻译48小时未提交请其他战友继续认领 Gene found for rare and deadly childhood cancer
WASHINGTON (Reuters) - Researchers have found a gene that causes most inherited forms of neuroblastoma, a rare and deadly form of childhood cancer, and say the discovery points to new treatments.
华盛顿（路透社）研究人员已经发现引起大多数遗传性神经母细胞瘤的基因，神经母细胞瘤是一种罕见的致死性的儿童肿瘤。研究人员称：这项发现为神经母细胞瘤新的治疗指明了方向。
Mutations in a gene called ALK were strongly linked to neuroblastoma, the researchers from the United States, Italy and Belgium reported on Sunday. They said several companies already are working on drugs that target this gene, which is also mutated in some cases of lung cancer and lymphoma.
来至美国、意大利、比利时的研究人员在星期天的时候报告称：一种名为ALK的基的因变异与神经母细胞瘤的发生有着很大的关系。他们说：这种基因的变异同样也引起几种肺癌和淋巴癌，已经有几家公司在开发作用于这种基因的药物
"This discovery enables us to offer the first genetic tests to families affected by the inherited form of this disease," said Dr. Yael Mosse of The Children's Hospital of Philadelphia, who worked on the study.
参与这项研究的费城儿童医院Yael Mosse博士说：“这个发现使我们首次能够为患遗传性神经母细胞瘤的家庭提供基因检测。”
"Furthermore, because there already are drugs in development that target the same gene in adult cancers, we can soon begin testing those drugs in children with neuroblastoma."
此外，由于已经有作用于相同基因但用于治疗成人癌症的药物正在开发，我们可以很快将这些药用于神经母细胞瘤患儿的测试。
Neuroblastoma accounts for 15 percent of childhood cancer deaths, with just a 40 percent survival rate, even though it only causes about 7 percent of all pediatric cancers.
尽管神经母细胞瘤只占儿科肿瘤的大约7%，但其却占儿童癌症死亡的15%，其存活率仅有40%。
Writing in the journal Nature, the team at Children's Hospital, the Scripps Research Institute in La Jolla, California, and elsewhere said they studied 20 families with one or more children with neuroblastoma.
一支由儿童医院和位于加利福利亚拉荷亚的斯克里普斯研究所以及来至其他地方的研究人员组成的研究小组在《自然》杂志上发表文章称，他们研究了20个家庭，每个家庭都至少有一到多名儿童患有神经母细胞瘤。
They found mutations in the ALK gene that cause it to be constantly active in helping cells proliferate. Out-of-control proliferation is the hallmark of cancer.
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作者:admin@医学,生命科学 2010-12-27 05:14
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