【Blood】B淋巴细胞发生和功能
The discovery that lymphocyte subpopulations participate in distinct components of the immune response focused attention onto the origins and function of lymphocytes more than 40 years ago. Studies in the 1960s and 1970s demonstrated that B and T lymphocytes were responsible primarily for the basic functions of antibody production and cell-mediated immune responses, respectively. The decades that followed have witnessed a continuum of unfolding complexities in B-cell development, subsets, and function that could not have been predicted. Some of the landmark discoveries that led to our current understanding of B lymphocytes as the source of protective innate and adaptive antibodies are highlighted in this essay. The phenotypic and functional diversity of B lymphocytes, their regulatory roles independent of antibody production, and the molecular events that make this lineage unique are also considered. Finally, perturbations in B-cell development that give rise to certain types of congenital immunodeficiency, leukemia/lymphoma, and autoimmune disease are discussed in the context of normal B-cell development and selection. Despite the significant advances that have been made at the cellular and molecular levels, there is much more to learn, and cross-disciplinary studies in hematology and immunology will continue to pave the way for new discoveries.
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The discovery that lymphocyte subpopulations participate in distinct components of the immune response focused attention onto the origins and function of lymphocytes more than 40 years ago. Studies in the 1960s and 1970s demonstrated that B and T lymphocytes were responsible primarily for the basic functions of antibody production and cell-mediated immune responses, respectively. The decades that followed have witnessed a continuum of unfolding complexities in B-cell development, subsets, and function that could not have been predicted. Some of the landmark discoveries that led to our current understanding of B lymphocytes as the source of protective innate and adaptive antibodies are highlighted in this essay. The phenotypic and functional diversity of B lymphocytes, their regulatory roles independent of antibody production, and the molecular events that make this lineage unique are also considered. Finally, perturbations in B-cell development that give rise to certain types of congenital immunodeficiency, leukemia/lymphoma, and autoimmune disease are discussed in the context of normal B-cell development and selection. Despite the significant advances that have been made at the cellular and molecular levels, there is much more to learn, and cross-disciplinary studies in hematology and immunology will continue to pave the way for new discoveries.
40年前，淋巴细胞亚群被发现是参与免疫反应的重要部分，由此引起人们对淋巴细胞来源和功能的关注。上世纪60－70年代研究表明抗体生成和细胞介导的免疫反应分别是B、T细胞主要基本功能。随后数十年的研究不断揭示了B细胞难以预测的发生、亚型和功能。这篇论文中强调许多里程碑式的发现，这使我们对B细胞产生的天然保护和适应性抗体有所了解。B淋巴细胞表型和功能的多样性，调节抗体产生的独立性及独有的分子事件联系也在文中涉及。最后，在正常B细胞发生和选择章节中讨论了B细胞发生过程中转换引起特定类型的先天性免疫缺陷病，白血病/淋巴瘤和自身免疫性疾病。尽管这些重要的发现是在细胞和分子水平，还有更多的需要研究，血液学和免疫学交叉学科研究将为新的发现奠定了基础。
学习了,谢谢,顶起来
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作者:admin@医学,生命科学 2010-12-20 17:11
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