主页 > 医学信息 >
【bio-news】脂肪在胖人与瘦人内的功能不同
A Temple University study finds fat in obese patients is "sick" when compared to fat in lean patients.
When our bodies don't work properly, we say we're sick. A study published in the September issue of Diabetes finds that the same could be said for fat tissue found in obese patients. The cells in their fat tissue aren't working properly and as a result, are sicker than cells found in lean patients' fat tissue.
Lead author Guenther Boden, M.D. theorizes that "sick fat" could more fully explain the link between obesity and higher risk of diabetes, heart disease and stroke.
Researchers from the departments of endocrinology, biochemistry and surgery at the Temple University School of Medicine took fat biopsies from the upper thighs of six lean and six obese patients and found significant differences at the cellular level.
"The fat cells we found in our obese patients were deficient in several areas," said Boden, Laura H. Carnell Professor of Medicine and chief of endocrinology. "They showed significant stress on the endoplasmic reticulum, and the tissue itself was more inflamed than in our lean patients."
Endoplasmic reticulum (ER) is found in every cell and helps synthesize proteins and monitor how they're folded. The stress that Boden describes causes the ER in fat cells to produce several proteins that ultimately lead to insulin resistance, which has been found to play a major role in the development and progression of obesity-related conditions.
The National Institutes of Health recently reported that each time a body mass index (BMI) over 25 is raised by one point, the risk for diabetes increases 25 percent and the risk for heart disease increases 10 percent.
Reducing weight can help reduce stress on the ER, which can lower the risk of insulin resistance and the resulting conditions. Currently Boden and his team are looking at whether free fatty acids are a potential cause for this ER stress.
Other authors on this study include Xunbao Duan, Carol Homko, Ezequiel J. Molina, WeiWei Song, Oscar Perez, Peter Cheung and Salim Merali of Temple University School of Medicine. Funding for this research was provided by grants from the National Institutes of Heath, the Groff Foundation and a mentor-based training grant from the American Diabetes Association.
http://www.sciencedaily.com/releases/2008/08/080827163816.htm 本人已认领本文翻译，48小时未提交请其他战友继续认领。 Not All Fat Is Created Equal: Fat In Obese Patients Is 'Sick' Compared To Fat From Lean Patients
A Temple University study finds fat in obese patients is "sick" when compared to fat in lean patients.
天普大学的一项研究发现与瘦人相比，在胖人身上的脂肪是“病态的”。
When our bodies don't work properly, we say we're sick. A study published in the September issue of Diabetes finds that the same could be said for fat tissue found in obese patients. The cells in their fat tissue aren't working properly and as a result, are sicker than cells found in lean patients' fat tissue.
当我们的身体不能正常工作时，我们就说我们生病了。而一项发表在9月卷《糖尿病》杂志上的研究发现，肥胖患者身上的脂肪组织也可以这么说。他们的脂肪组织中的的细胞不能正常工作结果同瘦人脂肪组织中的细胞先比就更病态。
Lead author Guenther Boden, M.D. theorizes that "sick fat" could more fully explain the link between obesity and higher risk of diabetes, heart disease and stroke.
主要作者Guenther Boden博士建立的“病态脂肪”的理论能够圆满地解释肥胖与患糖尿病、心脏病和中风更高的风险之间的关系。
Researchers from the departments of endocrinology, biochemistry and surgery at the Temple University School of Medicine took fat biopsies from the upper thighs of six and six obese patients and found significant differences at the cellular level.
来至天普大学医学院内分泌系、生化系和外科的研究人员分别从体重过轻和肥胖的病人的大腿上部取脂肪活检并在细胞水平发现了显著的差异。
"The fat cells we found in our obese patients were deficient in several areas," said Boden, Laura H. Carnell Professor of Medicine and chief of endocrinology. "They showed significant stress on the endoplasmic reticulum, and the tissue itself was more inflamed than in our lean patients."
Endoplasmic reticulum (ER) is found in every cell and helps synthesize proteins and monitor how they're folded. The stress that Boden describes causes the ER in fat cells to produce several proteins that ultimately lead to insulin resistance, which has been found to play a major role in the development and progression of obesity-related conditions.
“我们发现肥胖病人身上的脂肪细胞在几个层面上存在缺陷”Boden和医学教授、内分泌系主任Laura H. Carnell说“它们的内质网表现出极其显著的紧张状态且组织本身比体重过轻的病人的组织膨胀得更厉害。”每一细胞中都有内质网的存在，内质网帮助合成蛋白质并监视蛋白质的折叠。Boden所描述的紧张状态导致脂肪细胞的内质网产生几种蛋白质最终导致胰岛素抗性，而已经发现，胰岛素抗性在肥胖相关情况的发展和演进中扮演了重要角色。
阅读本文的人还阅读：
作者:admin@医学,生命科学 2010-12-12 17:11
医学,生命科学网