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【科普】母乳喂养半年以上可降低特定类型乳腺
Certain types of breast cancer may be rarer among women who breastfeed their babies for at least six months.
That finding comes from a new study published in today's advance online edition of Cancer.
The researchers, who included Amanda Phipps, MPH, of the Fred Hutchinson Cancer Research Center in Seattle, pooled data from two breast cancer studies that together included nearly 2,500 women aged 55-79 in Washington state. The group included 1,140 women who had had breast cancer.
All of the women completed questionnaires that included questions about their history of breastfeeding, age at first menstrual period, live births, and menopause.
Phipps and colleagues combed through the data looking for patterns that stood out among women with any of the following types of breast cancer:
Estrogen-sensitive breast cancer (the majority of breast cancers)
HER2-positive breast cancer (breast cancers with high levels of the HER2 protein)
"Triple negative" breast cancer (breast cancers not sensitive to estrogen or progesterone and not HER2-positive)
Breastfeeding for at least six months appeared to be most protective for "triple negative" breast cancer. Triple-negative breast cancer was half as common among women who reported breastfeeding their babies for six or more months than among mothers who hadn't breastfed.
By the same comparison, estrogen-sensitive breast cancer was 20% less common among women who breastfed for at least six months than among mothers who didn't breastfeed.
The reason for those findings isn't clear. The study doesn't prove that breastfeeding prevented breast cancer or that not breastfeeding raises breast cancer risk; observational studies, such as this one, don't prove cause and effect. But other observational research has linked breastfeeding to lower rates of breast cancer, Phipps' team notes.
Besides breastfeeding, two other patterns emerged:
Early menarche -- starting menstruation at or before age 13 -- was only linked to increased risk of HER2-positive breast cancer.
Late menopause -- after age 55 -- and use of estrogen-plus-progesterone hormone therapy were only linked to risk of estrogen-sensitive breast cancer
Phipps and colleagues considered other factors, including the women's education level, smoking status, alcohol consumption, and immediate family history of breast cancer. Still, they caution that relatively few women in the studies had HER2-positive or triple-negative breast cancer, which may have made it harder to spot trends in those types of cancer. Phipps' team concludes that "certain reproductive factors may have a greater impact" than others on the risk of developing certain subtypes of breast cancer and that further research is needed. Study: Breastfeeding for at Least 6 Months Is Linked to Lower Rates of Certain Breast Cancers
研究：母乳喂养至少6个月以上与某些乳腺癌患病率下降有关
Certain types of breast cancer may be rarer among women who breastfeed their babies for at least six months.
某些特定类型乳腺癌在采用母乳喂养至少6个月的妇女之中很少发现。
That finding comes from a new study published in today's advance online edition of Cancer.
那项发现来自于在线版Cancer今日发表的一项研究。
The researchers, who included Amanda Phipps, MPH, of the Fred Hutchinson Cancer Research Center in Seattle, pooled data from two breast cancer studies that together included nearly 2,500 women aged 55-79 in Washington state. The group included 1,140 women who had had breast cancer.
研究者包括来自西雅图Fred Hutchinson癌症研究中心的Amanda Phipps，他们的数据来自于两项乳腺癌研究一共包括在华盛顿州的将近2500名年龄在55-79之间的妇女。这些妇女其中1140人是乳腺癌患者。
All of the women completed questionnaires that included questions about their history of breastfeeding, age at first menstrual period, live births, and menopause.
所有的妇女都完成了问卷调查，其中包括一些问题比如母乳喂养史、初潮年龄、婴儿安全出生情况和绝经年龄。
Phipps and colleagues combed through the data looking for patterns that stood out among women with any of the following types of breast cancer:
phipps等人筛选出包含有以下任何一种乳腺癌妇女的数据：
Estrogen-sensitive breast cancer (the majority of breast cancers)
雌激素敏感型乳腺癌（占乳腺癌的大部分）
HER2-positive breast cancer (breast cancers with high levels of the HER2 protein)
HER2阳性乳腺癌（含有高水平HER2蛋白的乳腺癌）
"Triple negative" breast cancer (breast cancers not sensitive to estrogen or progesterone and not HER2-positive)
“三者阴性”乳腺癌（对雌孕激素不敏感并且没有HER2阳性的乳腺癌）
Breastfeeding for at least six months appeared to be most protective for "triple negative" breast cancer. Triple-negative breast cancer was half as common among women who reported breastfeeding their babies for six or more months than among mothers who hadn't breastfed.
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作者:admin@医学,生命科学 2010-12-03 05:11
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