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【medical-news】黑素体动态性和黑素瘤对化疗剂的
Print Submitted: 2009-8-24 Source: Journal of the National Cancer Institute
Manipulating the functions of melanosomes--the organelles in pigment-producing cells--may enhance the activity of anticancer drugs used against melanoma, according to a new study published online August 24 in the Journal of the National Cancer Institute.
To examine the role of melanosomes in the sensitivity of malignant melanoma to chemotherapeutic agents, Kevin Chen, Ph.D., Vincent Hearing, Ph.D., Michael M. Gottesman, M.D., of the Laboratory of Cell Biology at the National Cancer Institute in Bethesda, Md., and colleagues compared pigmentation and melanosome developmental stage, number, and cellular structures in melanoma cell lines in response to treatment with chemotherapeutic agents.
The authors found that late-stage melanosomes that were damaged and thus could not trap metabolites were toxic to melanoma cells. They also found that melanoma cells that survived cisplatin treatment had more stage II-III functional melanosomes—also known as early melansomes because they have not initiated melanin synthesis—than untreated melanoma cells. In addition, when melanosomes were reverted to relatively early stages, the melanoma cells became more resistant to cisplatin.
"We believe that manipulation of melanosome status either by cytotoxic or by noncytotoxic drugs opens therapeutic avenues and raises the prospect of successfully treating pigment-producing cell-related diseases and, in particular, highly intractable malignant melanomas," the authors write. 自己认领了，48h内翻译完 JNCI news brief: Melanosome dynamics and sensitivity of melanoma cells to chemotherapeutic agents
JNCI简要新闻：黑素体动态性和黑素瘤对化疗剂的和敏感性之间的关系
Manipulating the functions of melanosomes--the organelles in pigment-producing cells--may enhance the activity of anticancer drugs used against melanoma, according to a new study published online August 24 in the Journal of the National Cancer Institute.
根据一篇8月24日在线发表在国家肿瘤研究所杂志的文章，操控黑素体的功能——形成色素的细胞的细胞器——可能可以增强抗肿瘤药物抗黑素瘤的活性。
To examine the role of melanosomes in the sensitivity of malignant melanoma to chemotherapeutic agents, Kevin Chen, Ph.D., Vincent Hearing, Ph.D., Michael M. Gottesman, M.D., of the Laboratory of Cell Biology at the National Cancer Institute in Bethesda, Md., and colleagues compared pigmentation and melanosome developmental stage, number, and cellular structures in melanoma cell lines in response to treatment with chemotherapeutic agents.
为了检测黑素体在恶性核素刘对化疗剂的敏感性中的作用，贝塞斯达国家肿瘤研究所细胞生物学实验室的Kevin Chen, Ph.D., Vincent Hearing, Ph.D., Michael M. Gottesman, M.D.以及其他同事比较了在黑素瘤细胞体系对于化疗剂的应答性过程中，染色和和黑素体的发展阶段，数量以及细胞结构。
The authors found that late-stage melanosomes that were damaged and thus could not trap metabolites were toxic to melanoma cells. They also found that melanoma cells that survived cisplatin treatment had more stage II-III functional melanosomes—also known as early melansomes because they have not initiated melanin synthesis—than untreated melanoma cells. In addition, when melanosomes were reverted to relatively early stages, the melanoma cells became more resistant to cisplatin.
作者发现在晚期黑素体受到破坏因而无法固定对于黑素瘤细胞有毒性的代谢物。他们同样发现接受顺铂治疗后存活的黑素瘤细胞具有更多的阶段II-III的功能性黑素体——也称为早期黑素体，因为它们不启动黑色素合成——比未接受治疗的黑素瘤细胞。并且，当黑素体转换到相对早期阶段，黑素瘤细胞对顺铂的耐受性增强。
"We believe that manipulation of melanosome status either by cytotoxic or by noncytotoxic drugs opens therapeutic avenues and raises the prospect of successfully treating pigment-producing cell-related diseases and, in particular, highly intractable malignant melanomas," the authors write.
“我们相信通过细胞毒性或者非细胞毒性药物掌控黑素体状态可以开通治疗道路并成功治疗色素生成的细胞类相关疾病，并且，特别是极度难以对付的恶性黑素瘤细胞，”作者写道。 JNCI简要新闻：黑素体动态性和黑素瘤对化疗剂的和敏感性之间的关系
“我们相信通过细胞毒性或者非细胞毒性药物掌控黑素体状态可以开通治疗道路并成功治疗色素生成的细胞类相关疾病，并且，特别是极度难以对付的恶性黑素瘤细胞，”作者写道。
根据一篇8月24日在线发表在国家肿瘤研究所杂志的文章，操控黑素体的功能——形成色素的细胞的细胞器——可能可以增强抗肿瘤药物抗黑素瘤的活性。
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作者:admin@医学,生命科学 2010-11-11 17:11
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