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【medical-news】视网膜退行性病变治疗和诊断的曙
Yerkes researchers pave the way for earlier diagnosis and treatment of retinal degenerative diseases
First to successfully use MRI in animal models to capture images of eye's elusive retinal layers
ATLANTA ?In an unprecedented animal research study, researchers at the Yerkes National Primate Research Center, Emory University, and the Atlanta VA Hospital have used magnetic resonance imaging (MRI) to produce images of the eye誷 retinal layers. The research, which will publish in an online Early Edition of the Proceedings of the National Academy of Sciences, has the potential to revolutionize the way retinal degenerative diseases, such as retinitis pigmentosa, glaucoma, age-related macular degeneration and diabetic retinopathy, are diagnosed and treated. Accelerating detection and treatment of such diseases ultimately could help prevent vision loss.
"Currently available technologies for capturing images of the retina, such as fundus photography, allow doctors to view only surface vessels and structures," said lead researcher Timothy Q. Duong, PhD, director of magnetic resonance research at Yerkes and associate professor of neurology and radiology at Emory. "The most serious retinal diseases that cause vision loss, however, attack various cellular levels within the retina. Consequently, these diseases often are diagnosed only in the late stages, after irreversible damage has occurred," he continued.
To penetrate the deep layers of the retina and produce clear images, Dr. Duong and his research team made significant improvements in spatial resolution and sensitivity using Yerkes?state-of-the-art MRI technology. These improvements enabled them to non-invasively image structural oxygenation and functional changes in the rodent retinas and detect layer-specific changes in an animal model of retinitis pigmentosa, a degenerative disease that affects approximately 1.5 million people worldwide.
This technology also is applicable to other retinal diseases, which affect approximately 10 million Americans. For example, glaucoma causes gradual degeneration of cells of the optic nerve layer, which carries visual information from the eye to the brain. Also, age-related macular degeneration affects the part of the eye responsible for sharp central vision, and diabetic retinopathy is a common complication of uncontrolled diabetes and is the leading cause of blindness in people under 70.
"Because MRI technology is noninvasive and currently is used on people worldwide, extending this technology to imaging the retina should advance rapidly. Moreover, MRI has the unique advantage that it can provide useful physiological information, including structure, blood flow, oxygenation and function in a single setting," Dr. Duong noted. "The long-term goal is to bring this technology from the laboratory to the clinic where it may help prevent disease progression and vision loss through early diagnosis and intervention, and better monitoring of treatment." The next step is to test MRI retinal imaging in people. One of the challenges will be to find a way to reduce eye movements that can distort the MRI image. "We need to develop imaging protocols that capture information faster than the human eye can blink and co-register the time-series images in real time for diagnostic purposes," Dr. Duong concluded. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Yerkes researchers pave the way for earlier diagnosis and treatment of retinal degenerative diseases
Yerkes的观察者们找到了早期诊断和治疗视网膜退行性疾病的新方法
First to successfully use MRI in animal models to capture images of eye's elusive retinal layers
ATLANTA ?In an unprecedented animal research study, researchers at the Yerkes National Primate Research Center, Emory University, and the Atlanta VA Hospital have used magnetic resonance imaging (MRI) to produce images of the eye誷 retinal layers. The research, which will publish in an online Early Edition of the Proceedings of the National Academy of Sciences, has the potential to revolutionize the way retinal degenerative diseases, such as retinitis pigmentosa, glaucoma, age-related macular degeneration and diabetic retinopathy, are diagnosed and treated. Accelerating detection and treatment of such diseases ultimately could help prevent vision loss.
他们首次成功地运用MRI（磁共振成像）技术 在动物模型中捕捉到了眼球中的难以得到的视网膜层图像。
ATLANTA，一项史无前例的动物观察试验，研究者们在Yerkes国际研究中心Emory大学和Atlanta VA医院，采用磁共振成像（MRI）技术，得到了视网膜层的图像。这项研究发表在国家科学院学报的早报上。这种研究就视网膜退行性疾病的诊断和治疗而言具有潜在的革命性意义，这些疾病包括，着色性视网膜病变、青光眼、年龄相关的黄斑退行性改变以及糖尿病性视网膜病，。因为加快对这些疾病的诊断和治疗最终可以阻止视力的消失。
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作者:admin@医学,生命科学 2010-10-27 05:11
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