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【medical-news】专家找到癌症“基因密码”
29 Oct, 2006 2259hrs ISTAGENCIES
The mutated genes in breast and colon cancers are almost completely distinct, suggesting very different pathways for the development of each of these cancer types, say scientists.
Scientists in the US have cracked the entire genetic code of breast and colon cancers. The discovery could offer new treatment hopes and lead to better ways to diagnose cancer in its early, most treatable stages.
The genetic map shows that nearly 200 mutated genes, most previously unknown, help tumours emerge, grow and spread, *** reported on its website quoting Science.
Scientists at the Johns Hopkins Kimmel Cancer Center say the findings suggest cancer is more complex than experts had believed. The mutated genes in breast and colon cancers were almost completely distinct, suggesting very different pathways for the development of each of these cancer types.
Each individual tumour appeared to have a different genetic blueprint, which could explain why cancers can behave very differently from person to person, the scientists said.
"No two patients are identical," co-author Victor Velculescu explained. Now researchers will study how these mutations occur in breast and colon cancers. Previous cancer gene discoveries have already led to successful detection and treatment strategies.
For example, the breast cancer drug Herceptin targets a breast cancer cell receptor made by the Her2-neu gene. Blood tests for hereditary bowel cancer are based on the APC gene.
Anna Barker of the National Cancer Institute said: "Maximising the numbers of targets available for drug development in a specific cancer means that patients will ultimately receive more personalised, less toxic therapies."
Ed Yong of Cancer Research UK, said: "This is potentially a very important piece of research.","In the future, scientists hope to be able to tailor plans for preventing or treating cancer to each person's individual genetic profile. Studies like this can help us to accomplish this goal."
http://timesofindia.indiatimes.com/articleshow/222326.cms 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 专家破译癌症基因密码--------不同的变异基因导致不同的发展机制
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作者:admin@医学,生命科学 2010-10-18 05:11
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