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【medical-news】研究者发现短期(4w)放疗对于乳腺癌
Research finds shorter-course radiation treatment safe for breast cancer
研究者发现短期(4w)放疗对于乳腺癌患者副作用更小
External-beam radiation therapy for early-stage breast cancer can be delivered safely and in a shorter course that eliminates as much as two weeks from conventional treatment, finds a Fox Chase Cancer Center study presented today at the 48th Annual Meeting of the American Society for
Therapeutic Radiology and Oncology in Philadelphia.
短期疗法外线束放射治疗早期乳腺癌是副作用更小，它比传统放射疗法减少了两周多。福克斯•切斯癌症研究中心，今天在美国费城的第48界肿瘤放疗学大会上提出。
Many women with early-stage breast cancer are treated with breast-sparing surgery (lumpectomy) followed by external-beam radiation. The typical radiation course is delivered five days a week for six to seven weeks. In this phase II study presented today, researchers demonstrated that treatment length can be safely shortened to four weeks by increasing the daily dose delivered to the breast and lumpectomy site.
许多早期乳腺癌妇女进行乳腺保守治疗法治疗（局部肿块切除后进行放射治疗）。典型的疗程是每周5天治疗持续6－7周，今天第二阶段的研究提出，研究者证明疗程的长度可以被安全的缩短为四周，通过每天增加照射局部病灶组织的剂量。
A standard "boost," or increased dose, to the lumpectomy site usually takes an additional one and one-half to two weeks after the whole breast is treated with a standard radiation regimen. This study showed that the boost can be worked into a four-week course with similar side effects when compared to the longer standard treatment. Women reported acceptable side effects of breast or arm pain and high satisfaction with cosmetic results.
乳腺癌手术后对整个乳腺进行放疗后，对局部病灶组织进行剂量强度增加的照射，它持续一周半到两周的时间。这一研究表明：四周疗程（剂量增强）的副作用和较长的标准疗程相比是相似的。妇女可以接受乳癌副作用或手臂疼痛，对放疗后皮肤损伤程度很满意
"We know the standard regimen of daily radiation five days a week for six to seven weeks is a tremendous time commitment for women who are often still working or providing family care or both," said the study's lead author Gary Freedman, M.D., a radiation oncologist at Fox Chase Cancer Center in Philadelphia. "Our goal in this research was to reduce the burden of treatment time while maintaining a high level of quality of life issues."
美国费城福克斯•切斯癌症研究中心的放射肿瘤科医师，这一研究的主要领导者Gary Freedman医学博士说：我们知道每周5天治疗持续6周到7周放疗，对于仍然工作或顾家或两者兼顾的妇女来说，这么长的时间受限制是可怕的。我们研究目的就是减少治疗期间的负担，使之维持一个高水平的生活质量。
This is the first known study of its kind for breast cancer treatment involving intensity-modulated radiation therapy or IMRT. IMRT is a highly sophisticated system of delivering external-beam radiation that allows advanced planning for accuracy and reduced side effects.
这是首次研究使用调强适形放射治疗(IMRT) 治疗乳癌， IMRT是一种高精密的外线束放疗仪，它能提高靶区设计的精确性而减少副作用。
For the study, physicians administered a dose of radiation with IMRT to the entire breast for four weeks (20 daily treatments). During the same period, they added a radiation boost, a little each day, to the part of the breast where the tumor was removed (tumor bed). Because the boost is normally given for seven to 10 treatment fractions extra, the physicians were able to eliminate two weeks of treatment time.
在这一研究中，医生对整个乳癌组织用调强适形放射治疗仪实施四周的放射治疗。他们每天对乳癌切除病灶增加一点点照射剂量。因为增加了7到10次的照射次数，所以医生能减少两周的疗程。
The study included 75 patients and the end goal was to measure toxicity and cosmetic outcomes. Scores for toxicity and cosmetic outcomes were compared with historical data of women who received the usual longer course of therapy.
这一研究包括75个病人，最终的目的是评测毒副作用和皮肤外观。与通过已接受传统治疗（更长的疗程）的妇女的历史数据对比得出毒副作用和皮肤损伤发布
Toxicity results
The maximum dermatitis (skin inflamation) at the end of treatment was 12 percent with grade 0, 65 percent with grade 1, 23 percent with grade 2, and 0 with grade 3 or 4. Comparisons to women receiving conventional treatment used historical controls from the Radiation Therapy Oncology Group (8 percent with grade 0, 54 percent with grade 1, 36 percent with grade 2, and 1 percent with grade 3), and historical controls from Fox Chase (1 percent with grade 0, 21 percent with grade 1, 71 percent with grade 2, 8 percent with grade 3, and 1 percent with grade 4). By six weeks after treatment, all toxicity had resolved to a grade 0 or 1.
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作者:admin@医学,生命科学 2010-09-27 12:36
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