主页 > 医学信息 >
【medical-news】乳腺癌新的预后标记：GLI1
Source: BioMed Central
Elevated levels of GLI1 (glioma-associated oncogene homolog 1) protein in human breast cancer are associated with unfavorable prognosis and progressive stages of disease. Researchers writing in the open access journal BMC Cancer found increased expression of GLI1 in samples taken from more advanced and less survivable tumors.
Edgar Dahl led a team of researchers from RWTH Aachen's University Hospital who sought to evaluate whether GLI1 could represent a new prognostic marker in breast cancer treatment. He said, "GLI1, a mediator of the so-called 'hedgehog' signaling pathway, has previously been implicated in the development of different human tumor entities. We've found a positive, significant association between overexpression of GLI1 and unfavorable overall survival outcome in human breast cancer. This association has not been reported anywhere else so far, but similar tendencies were recently shown in human esophageal cancer".
The researchers studied samples of 229 invasive breast carcinomas taken from patients at the hospital, along with samples of normal human breast tissue for comparison. As well as poor survival, overexpression of the GLI1 protein was associated with tumor stage and lymph node status of the breast tumors analyzed. Dahl said, "Taken together, these results support a role of GLI1 as a new prognostic biomarker in breast cancer. Future studies will determine whether GLI1 can be successfully included into multimarker panels for early cancer detection or molecular sub-typing of breast cancer. This could support personalized breast cancer medicine". 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 New prognostic marker for human breast cancer
人乳腺癌新的预后标志物
Source: BioMed Central
资源来自：BioMed Central
Elevated levels of GLI1 (glioma-associated oncogene homolog 1) protein in human breast cancer are associated with unfavorable prognosis and progressive stages of disease. Researchers writing in the open access journal BMC Cancer found increased expression of GLI1 in samples taken from more advanced and less survivable tumors.
乳腺癌患者体内GLI1 (神经胶质瘤致病基因 1)蛋白的升高与疾病的不良预后和进展分期有关。研究者在开放获取期刊BMC肿瘤上的论文提示：来源于晚期或生存期短的乳腺癌标本，其GLI1是过表达的。
Edgar Dahl led a team of researchers from RWTH Aachen's University Hospital who sought to evaluate whether GLI1 could represent a new prognostic marker in breast cancer treatment. He said, "GLI1, a mediator of the so-called 'hedgehog' signaling pathway, has previously been implicated in the development of different human tumor entities. We've found a positive, significant association between overexpression of GLI1 and unfavorable overall survival outcome in human breast cancer. This association has not been reported anywhere else so far, but similar tendencies were recently shown in human esophageal cancer".
Edgar Dahl领导的来自RWTH Aachen大学医院的研究团队致力于评价GLI1是否可以成为乳腺癌治疗中新预后标志物。Edgar Dahl说：“GLI1，一种刺猬蛋白信号通路介质，参与不同实体瘤的发展过程。我们发现GLI1过表达与乳腺癌患者的不良预后之间有着阳性，有意义的相关性。这一相关性目前尚未在其他任何杂志上报道，但相似的趋势目前出现在食管癌的研究中”。
The researchers studied samples of 229 invasive breast carcinomas taken from patients at the hospital, along with samples of normal human breast tissue for comparison. As well as poor survival, overexpression of the GLI1 protein was associated with tumor stage and lymph node status of the breast tumors analyzed. Dahl said, "Taken together, these results support a role of GLI1 as a new prognostic biomarker in breast cancer. Future studies will determine whether GLI1 can be successfully included into multimarker panels for early cancer detection or molecular sub-typing of breast cancer. This could support personalized breast cancer medicine". 研究者研究的229例侵袭性乳腺癌标本来自医院的患者，并且用正常乳腺组织标本作对照。除不良生存外，GLI1蛋白过表达与肿瘤分期及分析乳腺癌的淋巴结状况相关。Dahl说：“总的来讲，这些研究结果支持GLI1作为乳腺癌新的预后生物标志物的作用。未来研究将确定GLI1是否能成功地纳入对早期癌症或乳腺癌分子亚型检测的多标志物参考标准。这也可以促进乳腺癌个体化治疗的发展”
--------------------------------------------------------------
编译
乳腺癌患者体内GLI1 (神经胶质瘤致病基因 1)蛋白的升高与疾病的不良预后和进展分期有关。研究者在开放获取期刊BMC肿瘤上的论文提示：来源于晚期或生存期短的乳腺癌标本，其GLI1是过表达的。
阅读本文的人还阅读：
作者:admin@医学,生命科学 2010-10-13 17:11
医学,生命科学网