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【medical-news】难治性高血压需当心阻塞性睡眠呼
NEW YORK (Reuters Health) Jan 11 - Obstructive sleep apnea syndrome is a major and independent risk factor for hypertension that does not respond to intensive antihypertensive treatment, according to study findings published in the December issue of Chest.
"Obstructive sleep apnea syndrome (OSAS) has been linked to resistant hypertension, but the magnitude of this association and its independence of confounding have not been established," write Dr. Flavio Danni Fuchs, of Hospital de Clinicas de Porto Alegre, Brazil, and colleagues.
In a case-control study, the researchers examined the association in 63 patients with resistant hypertension using at least three blood pressure-lowering drugs, including a diuretic, and 63 control subjects with controlled blood pressure receiving drug treatment. The main outcome was the frequency of OSAS, defined as an apnea-hypopnea index of at least 10 episodes per hour.
Cases and controls were well matched for confounding variables. Overall, 45 case patients (71%) and 24 controls (38%) had OSAS (p < 0.001). Results of a logistic regression analysis adjusting for gender, age, BMI, and duration of hypertension showed that OSAS was strongly and independently associated with resistant hypertension (odds ratio, 4.8).
"Comorbid OSAS should be considered in patients with resistant hypertension," Dr. Fuchs and colleagues conclude.
Chest 2007;132:1858-1862.
http://www.medscape.com/viewarticle/568690 Resistant Hypertension Linked to Sleep Apnea
难治性高血压与睡眠呼吸暂停相关
NEW YORK (Reuters Health) Jan 11 - Obstructive sleep apnea syndrome is a major and independent risk factor for hypertension that does not respond to intensive antihypertensive treatment, according to study findings published in the December issue of Chest.
纽约（路透健康）1月11日——据发表在12月chest杂志上的一篇文章报道，阻塞性睡眠呼吸暂停综合征是强化降压治疗效果较差的高血压的一个主要独立危险因素。
"Obstructive sleep apnea syndrome (OSAS) has been linked to resistant hypertension, but the magnitude of this association and its independence of confounding have not been established," write Dr. Flavio Danni Fuchs, of Hospital de Clinicas de Porto Alegre, Brazil, and colleagues.
就职于巴西Hospital de Clinicas de Porto Alegre的Flavio Danni Fuchs博士和其同事写道，“阻塞性睡眠呼吸暂停综合征(OSAS) 与难治性高血压具有相关性，但是两者的相关程度，以及是否独立于其他混杂因素，目前尚不清楚。
In a case-control study, the researchers examined the association in 63 patients with resistant hypertension using at least three blood pressure-lowering drugs, including a diuretic, and 63 control subjects with controlled blood pressure receiving drug treatment. The main outcome was the frequency of OSAS, defined as an apnea-hypopnea index of at least 10 episodes per hour.
在一项病例对照研究中，研究人员在63名难治性高血压患者和63名对照患者中对这种相关性（阻塞性睡眠呼吸暂停综合征与难治性高血压的相关性）进行了研究。其中，难治性高血压患者至少使用三种降压药，包括一种利尿剂。对照组为通过药物治疗血压得到控制的患者。研究的主要终点是OSAS的频率，用每小时至少发作10次的呼吸暂停低通气指数作为衡量指标。
Cases and controls were well matched for confounding variables. Overall, 45 case patients (71%) and 24 controls (38%) had OSAS (p < 0.001). Results of a logistic regression analysis adjusting for gender, age, BMI, and duration of hypertension showed that OSAS was strongly and independently associated with resistant hypertension (odds ratio, 4.8).
病例组和对照组根据混杂因素相匹配。总体来说，病例组有45例(71%) ，对照组有24例(38%) 发生 OSAS (p < 0.001)。校正了性别、年龄、体重指数（BMI）和高血压病程后的logistic回归分析显示， OSAS 与难治性高血压具有独立强相关性（OR 4.8）。
"Comorbid OSAS should be considered in patients with resistant hypertension," Dr. Fuchs and colleagues conclude.
“难治性高血压患者需考虑是否合并OSAS，" Fuchs博士和其同事总结道。
Chest 2007;132:1858-1862.
http://www.medscape.com/viewarticle/568690
编译：
难治性高血压患者需当心阻塞性睡眠呼吸暂停综合征
纽约（路透健康）1月11日——据发表在12月chest杂志上的一篇文章报道，阻塞性睡眠呼吸暂停综合征（OSAS）是难治性高血压的一个主要独立危险因素。难治性高血压患者需考虑是否合并OSAS。（Chest 2007;132:1858-1862.）
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作者:admin@医学,生命科学 2011-08-05 17:16
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