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【medical-news】高血压可预测女性新发2型糖尿病风
NEW YORK (Reuters Health) Jan 18 - New findings from the Women's Health Study show that baseline blood pressure and progressive increases in blood pressure are "strong and independent predictors" of incident type 2 diabetes in initially healthy women.
The findings, published in the December issue of the European Heart Journal, are reported by a team from Harvard Medical School in Cambridge, Massachusetts, and led by Dr. David Conen.
The current analysis involved 38,172 women without heart disease or diabetes at baseline. The investigators stratified them into four groups according to baseline blood pressure: group 1, < 120/75 mm Hg; group 2, 120-129/75-84 mm Hg; group 3, 130-139/85-89 mm Hg; and group 4, > 140/90 mm Hg, classified as hypertensive.
The primary outcome measure was the development of type 2 diabetes, which occurred in 1,672 women during 10.2 years of follow-up.
Multivariable adjusted hazard ratios for incident type 2 diabetes were 0.66 for group 1; 1.0 for group 2, which served as the reference group; 1.42 for group 3; and 2.03 for group 4.
For women with blood pressure progression during the first 48 months of follow-up but who remained normotensive, the hazard ratio for type 2 diabetes was 1.26, and it was 1.64 for those who developed hypertension during the first 48 months, compared to women with no blood pressure progression.
"Our study provides strong evidence that baseline blood pressure and blood pressure progression are associated with an increased risk of incident type 2 diabetes," Dr. Conen and colleagues conclude. "Clinicians should be aware of these relationships to optimize the management of patients at increased risk for cardiovascular disease."
In an accompanying editorial, Dr. Peter M. Nilsson of Lund University in Malmo, Sweden, comments that early intervention studies are needed. The findings ideally "would ask the question of whether lifestyle advice is superior, equal or inferior to drug therapy for cardiovascular prevention," he notes.
Eur Heart J 2007;28:2832-2833,2937-2943.
http://www.medscape.com/viewarticle/568999 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 High Blood Pressure Predicts New-Onset Type 2 Diabetes in Women
高血压能够预测女性新发糖尿病
NEW YORK (Reuters Health) Jan 18 - New findings from the Women's Health Study show that baseline blood pressure and progressive increases in blood pressure are "strong and independent predictors" of incident type 2 diabetes in initially healthy women.
纽约（路透社 健康）1月18日——女性健康研究的新发现显示健康女性基础血压和血压进展是发生2型糖尿病的“强而独立的危险因子”。
The findings, published in the December issue of the European Heart Journal, are reported by a team from Harvard Medical School in Cambridge, Massachusetts, and led by Dr. David Conen.
这些发现，发表在欧洲心脏杂志12月期，由哈佛医学院（剑桥、麻萨诸塞州）的一个团队报道，这个团队由David Conen博士领导。
The current analysis involved 38,172 women without heart disease or diabetes at baseline. The investigators stratified them into four groups according to baseline blood pressure: group 1, < 120/75 mm Hg; group 2, 120-129/75-84 mm Hg; group 3, 130-139/85-89 mm Hg; and group 4, > 140/90 mm Hg, classified as hypertensive.
这一研究纳入了38172名基线时没有心脏病和糖尿病的患者。调查者根据基线血压将他们分为四组：1组 <120/75mmHg；2组 120-129/75-84 mm Hg；3组 130-139/85-89 mm Hg；4组 > 140/90 mm Hg高血压组。
The primary outcome measure was the development of type 2 diabetes, which occurred in 1,672 women during 10.2 years of follow-up.
研究的主要终点为发生2型糖尿病，在10.2年的随访中，共有1672名女性发生了2型糖尿病。
Multivariable adjusted hazard ratios for incident type 2 diabetes were 0.66 for group 1; 1.0 for group 2, which served as the reference group; 1.42 for group 3; and 2.03 for group 4.
各组发生2型糖尿病的多因素校正的危险比为：1组 0.66；2组 1.0（作为参考值）；3组 1.42；4组 2.03。
For women with blood pressure progression during the first 48 months of follow-up but who remained normotensive, the hazard ratio for type 2 diabetes was 1.26, and it was 1.64 for those who developed hypertension during the first 48 months, compared to women with no blood pressure progression.
对于在随访的前48个月血压进展而血压仍然在正常范围的女性，发生2型糖尿病的危险比为1.26，而在48个月内发展到高血压的女性危险比为1.64，与没有血压进展的女性相比。
"Our study provides strong evidence that baseline blood pressure and blood pressure progression are associated with an increased risk of incident type 2 diabetes," Dr. Conen and colleagues conclude. "Clinicians should be aware of these relationships to optimize the management of patients at increased risk for cardiovascular disease."
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作者:admin@医学,生命科学 2011-07-30 17:33
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