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【文摘发布】避免并发症的免疫抑制方案:移植的
Author:Smallwood, Gregory A
Source:Current Opinion in Organ Transplantation. 11:613-616, December
IF: (unknown)
Purpose of review: The goal of solid organ transplantation has now evolved into minimizing the long-term consequences of immunosuppression. The consequences of immunosuppression include an increased risk of developing diabetes, renal insufficiency, osteoporosis, malignancies, and viral infections, to name but a few.
Recent findings: Immunosuppressive protocols that avoid or minimize the use of calcineurin inhibitors hold the promise of better long-term patient outcomes, especially with patients who progress on to dialysis or renal transplantation after organ transplantation. New, aggressive induction protocols have been used in patients with chronic viral infections, such as hepatitis C, without untoward effects on outcomes.
Summary: It is important to appreciate that the long-term benefits of new immunosuppressive strategies have yet to stand the test of time when considering long-term graft survival. Follow-ups to these recent studies should be incorporated and should have similar rates of acute rejection to ensure similar long-term outcomes. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 题目：避免并发症的免疫抑制策略：移植的致命弱点
作者：Smallwood, Gregory A
来源:Current Opinion in Organ Transplantation. 11 :613-616, December
IF: (unknown)
目的：实体器官移植发展到现在，进入了尽量减少长期的免疫抑制引起并发症的时期。免疫抑制可能导致：发生糖尿病的风险增高，肾衰，骨炙疏松，恶性肿瘤的发生和病毒感染。
最近发现：避免或者尽量减少神经钙蛋白抑制剂的应用的免疫抑制策略对于患者的长期预后有好处，尤其是在那些在器官移植后需要进行透析或者肾移植的患者。已经针对有慢性病毒感染的患者应用了积极的免疫诱导策略,如HCV患者，但是发现对患者的预后没有影响。
结论：考虑到移植物的长期存活率，评价目前正在试用的新型的免疫抑制策略的长期效益是十分重要的。应该综合分析这些最近的研究的随访结果，应该有比较稳定的急性排斥发生率，以确保其长期结果相似。 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-07-09 17:11
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