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【文摘发布】天然免疫基因受体多态性对移植后
Authors：Cervera C, Lozano F, Saval N, et al.
Source：Transplantation. 2007 Jun 15;83(11):1493-1500.
Abstract：BACKGROUND.: Genetically defined deficiencies in key components of the innate immune system have been associated with a greater risk of infection. The aim of this study was to assess the influence of genetic variability of innate immune receptors (mannose-binding lectin [MBL], mannose-associated serine-protease-2 [MASP-2], and Toll-like receptors [TLR4]) in the risk of infections after a kidney transplantation. METHODS.: All patients undergoing a kidney or kidney-pancreas transplantation during a 3-year period were included. Functionally relevant mutations in MBL2, MASP2, and TLR4 genes were determined by DNA sequencing. The incidence of major bacterial infections, asymptomatic cytomegalovirus (CMV) infection, and CMV disease were compared among groups. RESULTS.: There were no differences regarding major transplant characteristics among groups. Older age, requirements for posttransplant hemodialysis, and pretransplant diabetes, but not gene polymorphisms, were associated with a greater number of bacterial infections. In univariate analysis, low-MBL genotypes were associated with CMV disease in pretransplant CMV seropositive patients (P=0.015), whereas the TLR4 mutation was associated with higher risk of CMV primary infection (P=0.024). TLR4 mutation was an independent factor associated with CMV disease (odds ratio 5.84, 95% confidence interval 1.35-25.20, P=0.018). CONCLUSION.: Polymorphisms of innate immunity receptors, especially TLR4 mutation, were associated with higher risk of CMV disease, while susceptibility to other infectious disorders was not observed. 本人试者翻译此文
Title：The Influence of Innate Immunity Gene Receptors Polymorphisms in Renal Transplant Infections.
题目:天然免疫受体基因多态性对肾移植感染的影响
Authors：Cervera C, Lozano F, Saval N, et al.
作者: Cervera C, Lozano F, Saval N, et al
Source：Transplantation. 2007 Jun 15;83(11):1493-1500.
来源:移植2007 6 15;83(11):1493-1500.
BACKGROUND.: Genetically defined deficiencies in key components of the innate immune system have been associated with a greater risk of infection.
背景:天然免疫系统重要组份已明确的遗传缺陷与高感染风险相关.
The aim of this study was to assess the influence of genetic variability of innate immune receptors (mannose-binding lectin [MBL], mannose-associated serine-protease-2 [MASP-2], and Toll-like receptors [TLR4]) in the risk of infections after a kidney transplantation.
本研究的目的是要评估天然免疫受体(甘露醇结合凝集素[MBL],甘露醇相关丝氨酸蛋白激酶2[MASP-2]及Toll样受体[TLR4])遗传变异对肾移植高感染风险的影响.
METHODS.: All patients undergoing a kidney or kidney-pancreas transplantation during a 3-year period were included.
方法:所有3年内行肾移植或胰肾联合移植的患者纳入该研究
Functionally relevant mutations in MBL2, MASP2, and TLR4 genes were determined by DNA sequencing.
DNA测序检测MBL2, MASP2,和 TLR4基因功能相关突变.
The incidence of major bacterial infections, asymptomatic cytomegalovirus (CMV) infection, and CMV disease were compared among groups.
组内就主要细菌感染,无症状巨细胞病毒(CMV)感染及巨细胞病毒性疾病发生率进行比较.
RESULTS.: There were no differences regarding major transplant characteristics among groups. Older age, requirements for posttransplant hemodialysis, and pretransplant diabetes, but not gene polymorphisms, were associated with a greater number of bacterial infections.
结果:组内主要的移植前患者情况无差别. 高龄与移植后透析治疗及移植前糖尿病相关并和绝大多数感染相关,但和基因多态性无关.
In univariate analysis, low-MBL genotypes were associated with CMV disease in pretransplant CMV seropositive patients (P=0.015), whereas the TLR4 mutation was associated with higher risk of CMV primary infection (P=0.024).
在单变量分析.低MBL基因型在移植前血清CMV阳性患者与CMV疾病发生相关(P=0.015),而TLR4突变与发生CMV初次感染的高危性有关(P=0.024).
TLR4 mutation was an independent factor associated with CMV disease (odds ratio 5.84, 95% confidence interval 1.35-25.20, P=0.018).
TLR4突变是CMV疾病发生的相关独立因子(OR值5.84,95%可信区间1.35-25.2, P=0.018)
CONCLUSION.: Polymorphisms of innate immunity receptors, especially TLR4 mutation, were associated with higher risk of CMV disease, while susceptibility to other infectious disorders was not observed.
结论:天然免疫受体的多态性,特别是TLR4突变,与发生CMV疾病的高危性相关,但并未观察到易感染其他感染性疾病.
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题目:天然免疫受体基因多态性对肾移植感染的影响
作者: Cervera C, Lozano F, Saval N, et al
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作者:admin@医学,生命科学 2011-03-27 11:48
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