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【medical-news】偏头痛患者早期即有动脉功能的改
NEW YORK (Reuters Health) May 18 - Impaired arterial vasodilation and other abnormalities are seen in patients with migraine of recent onset, according to a report in the May 8th Neurology.
Migraine is associated with an increased risk of cardiovascular disorders, the authors explain, but the underlying mechanisms are unknown.
Dr. Jan N. de Hoon from K. U. Leuven, Belgium and colleagues investigated arterial structural and functional properties in 50 patients with a recent onset of migraine.
Brachial and aortic blood pressures were slightly but significantly higher among migraine patients than among controls, the authors report, but pulse pressures and heart rates did not differ between patients and controls.
Migraine patients also had a decreased diameter and compliance of their superficial muscular arteries, compared with controls, the results indicate.
After adjustment for age, height, mean arterial pressure, and heart rate, aortic augmentation index correlated independently with the presence of migraine, the researchers note, but aortic pulse wave velocity did not.
Flow-mediated dilatation response normalized to peak shear rate was significantly lower in migraine patients than in controls, the report indicates.
"Functional arterial properties are altered in patients with migraine of recent onset," the authors conclude. These results "strengthen our hypothesis that altered arterial properties are associated with migraine without being the consequence of vascular injury caused by repeated migraine attacks or vasoconstrictor drugs."
"Many questions remain," writes Dr. Gretchen E. Tietjen from The University of Toledo-Health Science Campus, Ohio in a related editorial, "but the study advances the science of migraine in an important direction, where the avenues of investigation may lead to improvement both in migraine and stroke prevention."
Neurology 2007;68:1563-1570,1555-1556.
http://www.medscape.com/viewarticle/556963 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 Arterial Function Altered Early in Migraine Patients
偏头痛患者早期即有动脉功能的改变偏头痛患者早期即有动脉功能的改变
NEW YORK (Reuters Health) May 18 - Impaired arterial vasodilation and other abnormalities are seen in patients with migraine of recent onset, according to a report in the May 8th Neurology.
纽约（健康通讯社）5月18日-根据5月8号的一份报道，受损伤的动脉血管扩张和其它异常的情况都能在患偏头痛的初期病人中见到。
Migraine is associated with an increased risk of cardiovascular disorders, the authors explain, but the underlying mechanisms are unknown.
作者解释说，偏头痛是和患心血管病症增加的危险相联系的，但是这种联系的潜在机制还不太清楚。
Dr. Jan N. de Hoon from K. U. Leuven, Belgium and colleagues investigated arterial structural and functional properties in 50 patients with a recent onset of migraine.
来自比利时，列弗的Jan博士和他的同事们研究了50位具有初期患偏头痛的病人的动脉结构和功能的性质。
Brachial and aortic blood pressures were slightly but significantly higher among migraine patients than among controls, the authors report, but pulse pressures and heart rates did not differ between patients and controls.
作者报道，患偏头痛的病人和对照组相比，前者支动脉和主动脉压力不是轻微而是明显高于后者，但是脉压和心率在两者之间没有差别。
Migraine patients also had a decreased diameter and compliance of their superficial muscular arteries, compared with controls, the results indicate.
结果指出，与对照组比较，患偏头痛的病人也有浅表肌肉动脉直径减小和萎缩。
After adjustment for age, height, mean arterial pressure, and heart rate, aortic augmentation index correlated independently with the presence of migraine, the researchers note, but aortic pulse wave velocity did not.
研究人员指出，在年龄、身高、平均动脉压、心率调整以后，主动脉增加指数只和偏头痛病人相关，但是脉冲速度没有增加。
Flow-mediated dilatation response normalized to peak shear rate was significantly lower in migraine patients than in controls, the report indicates.
报告指出，流量介导的肱动脉扩张与标准的高峰速度阶差相比，偏头痛病人扩张流量低于对照组。
"Functional arterial properties are altered in patients with migraine of recent onset," the authors conclude. These results "strengthen our hypothesis that altered arterial properties are associated with migraine without being the consequence of vascular injury caused by repeated migraine attacks or vasoconstrictor drugs."
作者结论说，偏头痛的早期病人功能性动脉性质是可以改变的。这个结果也增强了这个假说，改变的动脉特性是和偏头痛相关的，而并不是受偏头痛的发作或是血管收缩药的血管损伤而引起的。
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作者:admin@医学,生命科学 2011-05-23 05:11
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