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【Gastroenterology】GERD和结直肠癌发生率虽体重指数
Dr. Frank K. Friedenberg and colleagues from Temple University School of Medicine in Philadelphia provide an extensive overview of scientific research on the epidemiologic and pathophysiologic associations between obesity and GERD.
Several studies featured in the article highlight the correlation between increasing body mass index (BMI) and the frequency and severity of acid reflux symptoms. One particular study found that accumulation of abdominal fat, as measured by the waist-to-hip ratio, may be the most important risk factor for the development of acid reflux and related complications such as Barrett's esophagus and esophageal adenocarcinoma.
The authors also examined data on the effects of weight loss through diet or surgical methods on acid reflux disease. Several studies suggest weight loss through caloric restriction was beneficial in reducing GERD symptoms. When the authors compared the different surgical approaches for weight loss, a surgical technique called "Roux-en-Y" gastric bypass appeared to be the best method, and was most consistently associated with improvement in the symptoms and findings of GERD. "The mechanism of action through which this surgery is successful at improving GERD may be independent of weight loss and needs further examination," said Dr. Friedenberg. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 The prevalence of obesity and overweight in the United States coupled by the increased risk of gastrointestinal diseases related to obesity raises serious implications for the health of Americans. Several scientific studies in the August issue of The American Journal of Gastroenterology examine the association between obesity and the risk of colorectal cancer and gastroesophageal reflux disease, or GERD.
随着美国肥胖和超重的广泛流行，胃肠疾病发病率的增长，导致了肥胖所导致的美国人健康威胁增加。八月份发表在美国胃肠杂志上数个科学研究调查了肥胖和直肠癌风险、胃食管反流病（GERD）的关系。
Dr. Frank K. Friedenberg and colleagues from Temple University School of Medicine in Philadelphia provide an extensive overview of scientific research on the epidemiologic and pathophysiologic associations between obesity and GERD.
来自费城Temple大学医学院的Dr. Frank K. Friedenberg和他的同事从流行病学和病理生理学的角度阐述肥胖和GERD的关系，并提供了一系列科研文献。
Several studies featured in the article highlight the correlation between increasing body mass index (BMI) and the frequency and severity of acid reflux symptoms. One particular study found that accumulation of abdominal fat, as measured by the waist-to-hip ratio, may be the most important risk factor for the development of acid reflux and related complications such as Barrett's esophagus and esophageal adenocarcinoma.
该文章提及的数项研究着重强调了增长的体重指数BMI和反酸发生率、严重性之间的关系。一项特别的研究发现用腰腹比率来表示的腹部脂肪蓄积可能是决定反酸症状发生的最重要危险因素，并与多个综合征相联系，如Barrett's食管和食管腺癌。
The authors also examined data on the effects of weight loss through diet or surgical methods on acid reflux disease. Several studies suggest weight loss through caloric restriction was beneficial in reducing GERD symptoms. When the authors compared the different surgical approaches for weight loss, a surgical technique called "Roux-en-Y" gastric bypass appeared to be the best method, and was most consistently associated with improvement in the symptoms and findings of GERD. "The mechanism of action through which this surgery is successful at improving GERD may be independent of weight loss and needs further examination," said Dr. Friedenberg.
作者们也试验了通过饮食或手术方法进行减肥在预防反酸的效果。数个研究表明，通过控制能量摄入的减肥有利于减少GERD症状。但作者对比了进行减肥的不同手术方法，称为"Roux-en-Y"胃旁路术是最好的方法，在减少GERD上的效果最持久。Dr. Friedenberg 表示“通过该手术提高GERD控制的机制可能是独立的，并需要进一步研究”
随着美国肥胖和超重的广泛流行，胃肠疾病发病率的增长，导致了肥胖所导致的美国人健康威胁增加。八月份发表在美国胃肠杂志上数个科学研究调查了肥胖和直肠癌风险、胃食管反流病（GERD）的关系。
来自费城Temple大学医学院的Dr. Frank K. Friedenberg和他的同事从流行病学和病理生理学的角度阐述肥胖和GERD的关系，并提供了一系列科研文献。
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作者:admin@医学,生命科学 2011-02-25 05:14
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