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【bio-news】中国科学家利用猪成体骨髓干细胞生成
据最新一期国际人造器官学会会刊《人造器官》（Artificial Organs）报道，中国科学家在最新研究中，成功利用猪的成体骨髓干细胞生成皮肤。报道称，这项成果是创伤愈合和器官构建方法研究中的一大进展。
据报道，中国第四军医大学组织工程研发中心主任金岩领导的研究小组，建立了猪的皮肤烧伤模型，以研究含有骨髓干细胞的人造皮肤修复烧伤创面的实用性。猪的皮肤在解剖学和生理学上与人的皮肤比较接近。
运用工程学技术和生物医学理论，研究人员构建了含有天然材料和猪成体骨髓干细胞的人造皮肤，将该皮肤敷贴于猪皮肤的烧伤创面，猪皮肤的真皮层开始再生，骨髓干细胞分化为多种皮肤细胞，猪皮肤的烧伤创面也开始缩小。
皮肤是人体最大的器官，是保护人体不受疾病和物理损伤的屏障，同时有助于调节体温。一旦皮肤由于疾病或者烧伤导致严重缺损，机体自身不能很快修复。大量烧伤患者往往死于感染和体液流失，皮肤移植是阻止这些并发症的有效方法。
金岩1月18日接受记者电话采访时表示，这一技术有望在皮肤烧伤治疗方面得到应用，如果将来找到合适的支架材料和干细胞，还有望利用这项技术修复受损的关节或骨骼。
Tissue-Engineered Skin Containing Mesenchymal Stem Cells Improves Burn Wounds
*†‡Peng Liu, §Zhihong Deng, ‡Shufang Han, *†Tao Liu, ¶Ning Wen, *†Wei Lu, †Xianhui Geng, *†Sha Huang, and *†Yan Jin
*Department of Oral Histology and Pathology, School of Stomatology; †Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi'an, Shaanxi; ‡General Hospital of Jinan Military Region, PLA, Jinan, Shandong; §Department of Otolaryngology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi; and ¶Department of Stomatology, Beijing 301 General Hospital of PLA, Beijing, China
Correspondence to Prof. Yan Jin, Department of Oral Histology and Pathology, School of Stomatology, Fourth Military Medical University, Xi'an, Shaanxi 710032, China. E-mail: yanjin@fmmu.edu.cn
Copyright Journal compilation © 2008 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.
KEYWORDS
Animal model • Mesenchymal stem cells • Wound healing • Tissue engineering
ABSTRACT
There is increasing evidence showing that adult stem cells are useful for tissue regeneration. Bone marrow mesenchymal stem cells (MSCs) are self-renewing and are potent in differentiating into multiple cells and tissues. To investigate the practicability of repairing burn wounds with tissue-engineered (TE) skin combined with bone MSCs, we established a burn wound model in the porcine skin. With a controlling temperature and time of the burning device to obtain different degrees of burn wounds, a deep dermal partial thickness burn was introduced to the porcine skin using a heated-brass contact injury at 100°C for 20 s. Collagen-GAG scaffolds were utilized as the matrix; MSCs separated from pigs were seeded on them to form the skin equivalent. When grafted to the burn wounds, the TE skin containing MSCs showed better healing and keratinization, less wound contraction, and more vascularization. Grafts proliferated well and contributed to the neo-tissues. These data suggest that TE skin containing MSCs in a burn defect can accelerate wound healing and receive satisfactory effects. 美国《每日科学》报道
Bone Marrow Stem Cells Used To Regenerate Skin
http://www.sciencedaily.com/releases/2009/01/090114160548.htm
ScienceDaily (Jan. 19, 2009) — A new study suggests that adult bone marrow stem cells can be used in the construction of artificial skin. The findings mark an advancement in wound healing and may be used to pioneer a method of organ reconstruction. The study is published in Artificial Organs.*
To investigate the practicability of repairing burn wounds with tissue-engineered skin combined with bone marrow stem cells, the study established a burn wound model in the skin of pigs, which is known to be anatomically and physiologically similar to human skin.
Engineering technology and biomedical theory methods were used to make artificial skin with natural materials and bone marrow derived stem cells. Once the artificial skin was attached to the patient and the dermal layer had begun to regenerate, stem cells were differentiated into skin cells. The cells are self-renewing and raise the quality of healing in wound healing therapy. When grafted to the burn wounds, the engineered skin containing stem cells showed better healing, less wound contraction and better development of blood vessels.
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作者:admin@医学,生命科学 2011-02-13 17:12
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