主页 > 医学新闻 >

【文摘发布】《Obstetrics and Gynecology》( 2007年6月

Influence of the Gynecologic Oncologist on the Survival of Ovarian Cancer Patients 顶起来 本人已认领该文编译,48小时后若未提交译文,请其他战友自由认领。 Influence of the Gynecologic Oncologist on the Survival of Ovarian Cancer Patients

妇科肿瘤医师对卵巢癌患者生存的影响

OBJECTIVE: To estimate the influence of gynecologic oncologists on the treatment and outcome of patients with ovarian cancer.
目的:评估妇科肿瘤医师对卵巢癌患者治疗和预后的影响
METHODS: Data were obtained from from 1994 to 1996. Kaplan-Meier and Cox proportional hazard methods were used for analyses.
方法:收集1994-1996就诊于California Cancer Registry患者的数据,运用Kaplan-Meier生存分析和Cox风险比例模型进行分析。
RESULTS: Of 1,491 patients, the median age was 65 years (range. Only 34.1% received care by gynecologic oncologists (group A) while 65.9% were treated by others (group B ) .
结果:1491的患者的中位年龄为65岁(13–100岁),其中仅34.1%的患者经妇科肿瘤医师诊治(A组),而65.9%的患者由其他专科的医师处理(B组)。
Women in group A were more affluent (P<.001), were more educated (P=.036), were classified as white-collar employees (P=.128), and lived in urban regions (P<.001) compared with group B.
与B组相比,A组的女性生活更富裕(P<.001),所受教育程度更高(P=.036),多居住在城市(P<.001),多为白领(P=.128)。
Patients who saw gynecologic oncologists were more likely to have surgery as their initial treatment (91.9% versus 69.1%; P<.001), present with advanced (stage III-IV) cancers (78.2% versus 70.5%; P<.001), have more grade 3 tumors (61.7% versus 39.9%; P=.048), and receive chemotherapy (90.0% versus 70.1%; P<.001).
到妇科肿瘤医师出就诊的大部分患者首次均接受手术治疗(91.9% versus 69.1%; P<.001),78.2%患者已达晚期(stage III-IV)大于B组的70.5%(P<.001),所患肿瘤多处三级(61.7% versus 39.9%; P=.048),她们中的大部分人均接受了化疗(90.0% versus 70.1%; P<.001)。
Women in group B had a fourfold higher risk of having unstaged cancers (8.0% versus 2.1%; P<.001).
B组的女性所患肿瘤处于未分级的更多(8.0% versus 2.1%; P<.001)。
The 5-year disease-specific survival of group A patients was 38.6% compared with 30.3% in group B (P<.001). A组的5年生存率显著高于B组(38.6% vs 30.3%,P<.001 )。
On multivariable analysis, early stage, lower grade, and treatment by gynecologic oncologists were independent prognostic factors for improved survival.
多因素分析表明,肿瘤处于早期,低分级和妇科肿瘤医师治疗是提高卵巢癌患者生存的独立预后因素。
After adjusting for surgery and chemotherapy, there was no improvement in survival associated with care by gynecologic oncologists (hazard ratio=0.90, 95% confidence interval 0.78–1.03; P=.133).
除了手术和化疗之外,妇科肿瘤医师没有其它与提高患者生存相关的治疗方式了(hazard ratio=0.90, 95% confidence interval 0.78–1.03; P=.133)。

CONCLUSION: In this study of 1,491 women, those who were treated by gynecologic oncologists were more likely to undergo primary staging surgery and receive chemotherapy. Stage, grade of disease, and treatment by gynecologic oncologists were important prognosticators.
结论:进入本研究的1491患者中,经由妇科肿瘤医师治疗的患者更易接受早期手术和化疗。 临床分期、肿瘤分级和妇科肿瘤医师治疗是影响卵巢癌患者生存的重要因素。

LEVEL OF EVIDENCE: II
证据级别:二级

妇科肿瘤医师对卵巢癌患者生存的影响

目的:评估妇科肿瘤医师对卵巢癌患者治疗和预后的影响
方法:收集1994-1996年就诊于California Cancer Registry患者的数据,运用Kaplan-Meier生存分析和Cox风险比例模型进行分析。
结果:1491的患者的中位年龄为65岁(13–100岁),其中仅34.1%的患者经妇科肿瘤医师诊治(A组),而65.9%的患者由其他专科的医师处理(B组)。与B组相比,A组的女性生活更富裕(P<.001),所受教育程度更高(P=.036),多居住在城市(P<.001),多为白领(P=.128)。
到妇科肿瘤医师出就诊的大部分患者首次均接受手术治疗(91.9% versus 69.1%; P<.001),78.2%患者已达晚期(stage III-IV)大于B组的70.5%(P<.001),所患肿瘤多处三级(61.7% versus 39.9%; P=.048),她们中的大部分人均接受了化疗(90.0% versus 70.1%; P<.001)。B组的女性所患肿瘤处于未分级的更多(8.0% versus 2.1%; P<.001)。A组的5年生存率显著高于B组(38.6% vs 30.3%,P<.001 )。多因素分析表明,肿瘤处于早期,低分级和妇科肿瘤医师治疗是提高卵巢癌患者生存的独立预后因素。除了手术和化疗之外,妇科肿瘤医师没有其它与提高患者生存相关的治疗方式(hazard ratio=0.90, 95% confidence interval 0.78–1.03; P=.133)。

阅读本文的人还阅读:

【文摘发布】AJOG(2007年

【nature要览】2007年5月

作者:admin@医学,生命科学    2011-02-13 17:12
医学,生命科学网