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【medical-news】早期干预并未改变局限性肾癌的五
The researchers charted survival rates from 1989 through 2004 in 1,618 patients with localized kidney cancer who underwent nephrectomies at their institution.
Patients were categorized by year of surgery (1989 to 1992, 1993 to 1996, 1997 to 2000, and 2001 to 2004) as well as by tumor size (less than 2 cm, 2-4 cm, 4-7 cm and greater than 7 cm).
In the July 1 issue of Cancer, Dr. Paul Russo and colleagues report that 16 patients (1%) developed local recurrences after nephrectomy and 163 patients (10%) developed distant metastases.
Trends in progression-free survival did not change over time, including no improvement in survival, Dr. Russo's team reports. Survival rates range from 79% to 84%, they say.
When five-year survival was calculated according to tumor size and in four-year cohorts, patients in more contemporary cohorts were more likely to undergo partial nephrectomy rather than radical nephrectomy. They were less likely to undergo lymph node dissection and adrenalectomy during resection compared with historic cohorts.
The MSKCC team writes that "pathologic stage and tumor grade were associated with disease progression, whereas patient age and tumor stage were associated with overall patient survival."
Dr. Russo and colleagues note that their findings "argue for the consideration of active surveillance for patients who have select renal tumors and a re-evaluation of the current treatment paradigm of surgically removing solid renal masses on initial detection."
Cancer 2008;113:84-96. [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-02-11 17:14
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