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【JCEM】意大利妇女产后持续存在甲状腺炎
意大利妇女产后持续存在甲状腺炎
NEW YORK (Reuters Health) Jan 13 - The majority of women who develop postpartum thyroiditis are not euthyroid a year later, a situation that calls for screening and treatment, researchers report in a December 29th online paper in the Journal of Clinical Endocrinology & Metabolism.
纽约（路透社健康频道）1月13日 研究人员在12月29日《美国临床内分泌与代谢杂志》在线发表的论文中报告，患产后甲状腺炎的妇女大多数在一年以后甲状腺功能仍不正常，这种情况应该进行检查和治疗。
"Postpartum thyroiditis is one of the most common endocrine disorders, impacting 4% of Italian women. Over half of the women who developed postpartum thyroiditis in the present study remained hypothyroid at one year following delivery," Dr. Alex Stagnaro-Green told Reuters Health by email.
“产后甲状腺炎是最常见的内分泌疾病之一，在意大利妇女中发病率为4％。本研究中患产后甲状腺炎的妇女中，有一半在产后一年甲状腺功能仍减退”。 Alex Stagnaro-Green博士通过电子邮件告诉路透社记者。
Dr. Stagnaro-Green, of George Washington University School of Medicine and Health Sciences, Washington, D.C., and colleagues came to this conclusion after studying two groups of women in southern Italy, an area of mild iodine deficiency.
Stagnaro-Green博士来自Washington, D.C.州George Washington大学医学和健康科学院，他和他的同事们研究了意大利南部的轻度缺碘地区的两组妇女后得出这一结论。
In all, 4394 women were screened for thyroid function and thyroid autoantibodies at 6 and 12 months postpartum. They were classified as high risk if they had factors including a family history and signs and symptoms of thyroid dysfunction.
总共4394例妇女在产后6~12个月筛查了甲状腺功能和甲状腺自身抗体。如果她们有包括家族史、甲状腺功能的症状和体征，则被列为高风险。
The risk of postpartum thyroiditis was significantly elevated in the high-risk group (odds ratio, 6.69).
高危人群组产后甲状腺炎的风险显著升高（风险比：6.69）。
In total, 169 (3.9%) of the women had postpartum thyroiditis. Of this group 82% had a hypothyroid phase during the first postpartum year. At the end of that year, 54% of the women had persistent hypothyroidism.
总共169例妇女（3.9％）患有产后甲状腺炎。其中82％在产后第一年存在甲减阶段。一年后，54％的妇女存在持续性甲状腺功能减退。
"This has important health implications," continued Dr. Stagnaro-Green, "as not only will many women be symptomatic, but it could have a negative impact on the subsequent pregnancy if the woman becomes pregnant without appropriate treatment."
“这是重要的健康问题”， Stagnaro-Green博士继续说道，“因为不仅许多妇女没有症状，而且如果没有适当的治疗的怀孕的话，可以对以后妊娠造成不良影响”。
He and his colleagues conclude that "it will be important to evaluate thyroid function tests at 1 year postpartum in all women with PPT to identify individuals with ongoing hypothyroidism who require levothyroxine treatment."
他和他的同事得出结论，“对所有患产后甲状腺炎的妇女在产后1年进行甲状腺功能测评估，以确定需要左甲状腺激素治疗的甲状腺功能减退的患者是非常重要的。”
J Clin Endocrinol Metab. Posted online December 29, 2011.
滨州医学院附属滨州市人民医院内分泌科 王新军 译 [标签:content2]
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作者:admin@医学,生命科学 2011-01-28 08:35
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