主页 > 医学新闻 >
【medical-news】胰岛素抵抗与炎症间的分子联系
Molecular Link Found Between Insulin Resistance And Inflammation
ScienceDaily (Aug. 27, 2009) — An exploration of the molecular links between insulin resistance and inflammation may have revealed a novel target for diabetes treatment, say scientists at the John G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh of UPMC. Their findings were published earlier this month in the online version of Diabetes, one of the journals of the American Diabetes Association.
Signs of low-grade systemic inflammation are not uncommon among people who have the pre-diabetic condition known as metabolic syndrome, as well as in animal models of obesity and type 2, or insulin-resistant, diabetes, said senior author H. Henry Dong, Ph.D., assistant professor, Department of Pediatrics, University of Pittsburgh School of Medicine.
"But it's not yet clear if there is a cause-and-effect relationship between chronic exposure to low-grade inflammation and the onset of insulin resistance," he explained. "Other studies have shown that in patients who have inflammation and diabetes, insulin-sensitizing drugs seem to reduce inflammation while anti-inflammatory therapies improve sensitivity to insulin."
Dr. Dong's team examined the role played by a protein called Forkhead Box 01 (Fox01), which his previous research showed contributes to elevations in triglycerides in an animal model of obesity and diabetes.
In the current paper, the researchers found in cultured cells and mouse experiments that Fox01 stimulates inflammatory white blood cells called macrophages, which migrate to the liver and adipose, or fat, tissue in insulin-resistant states, to increase production of a cytokine called interleukin-1 beta (IL-1. The cytokine in turn interferes with insulin signaling. Insulin typically inhibits Fox01, setting up a feedback loop in healthy tissues that helps regulate insulin levels.
"The findings suggest that when there is a lack of insulin or when cells such as macrophages are resistant to its presence, there are no brakes on Fox01's stimulation of IL-1B and its further interference with insulin signaling," Dr. Dong said. "That might explain why chronic inflammation often is coupled with obesity and type 2 diabetes. Also, a drug that acts on Fox01 might be able to better control blood sugar."
According to the ADA, an estimated 24 million Americans have type 2 diabetes, formerly known as adult-onset diabetes. As obesity becomes more common, however, the prevalence is rising in children. In type 2 diabetes, the body becomes resistant to the effect of insulin, leading to elevated blood sugar levels.
Co- authors of the paper include lead author Dongming Su, M.D., Gina M. Coudriet, Dae Hyun Kim, Ph.D., German Perdermo, Ph.D., Shen Qu, M.D., Sandra Slusher, Hubert M. Tse, Ph.D., Jon Piganelli, Ph.D., and Nick Giannoukakis, Ph.D., all of the Division of Immunogenetics, Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC and Pitt School of Medicine, and Yi Lu, Ph.D., and Jian Zhang, M.D., Division of Hematology and Oncology, Department of Medicine, Pitt School of Medicine.
The study was funded by the American Diabetes Association and the National Institutes of Health. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Molecular Link Found Between Insulin Resistance And Inflammation
胰岛素抵抗与炎症之间的分子联系被发现
ScienceDaily (Aug. 27, 2009) — An exploration of the molecular links between insulin resistance and inflammation may have revealed a novel target for diabetes treatment, say scientists at the John G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh of UPMC. Their findings were published earlier this month in the online version of Diabetes, one of the journals of the American Diabetes Association.
UPMC匹兹堡儿童医院，John G. Rangos Sr.研究中心的科学家透露：一项对胰岛素抵抗和炎症之间分子层面联系的探索，或许能为糖尿病治疗找到新的靶点。他们的发现发表在这个月早些时候的Diabetes在线版，它是属于ADA（美国糖尿病协会）的杂志之一
Signs of low-grade systemic inflammation are not uncommon among people who have the pre-diabetic condition known as metabolic syndrome, as well as in animal models of obesity and type 2, or insulin-resistant, diabetes, said senior author H. Henry Dong, Ph.D., assistant professor, Department of Pediatrics, University of Pittsburgh School of Medicine.
匹兹堡大学医学院儿科助理教授，H. Henry Dong博士说，对那些有前驱糖尿病症状，也就是代谢综合症的人们来说，有低水平系统性炎症的征兆是很常见的，这种情况在动物模型，比如肥胖，和II型糖尿病模型也就是胰岛素抵抗糖尿病模型中也同样存在。
阅读本文的人还阅读：
作者:admin@医学,生命科学 2010-10-11 17:11
医学,生命科学网