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【medical-news】HIV可存在于滤泡树突细胞中而避免
According to the Morning News, researchers have long believed that there are reservoirs in the body that allow HIV to remain in an infectious state despite treatment. FDCs are the third reservoir to be identified. The other two reservoirs are macrophages and CD4+ T cells infected with a latent form of HIV. FDCs store material needed to maintain antibodies in the immune system and release proteins to trigger production of certain antibodies if they become low.
Greg Burton, professor of chemistry and biochemistry at BYU, and colleagues discovered FDCs by analyzing samples from HIV-positive people. The researchers discovered that FDCs, which are located in lymph nodes, trap HIV on their services. The trapped HIV does not show behavior -- such as replicating or mutating -- that is targeted by antiretrovirals and, therefore, is able to avoid the drugs, according to Burton.
The researchers found several forms of HIV on FDC surfaces, suggesting that the virus does not mutate but acquires new samples over time. The researchers established a time frame for each version of the virus and sequenced the individual HIV genomes from the FDCs to compare with samples from other cells. According to the study, HIV takes advantage of FDCs' ability to create new versions of the virus by staying active, avoiding treatment that could eradicate the virus and by infecting other cells.
Burton said that although FDCs can store the virus and reignite HIV infection, the cells potentially could provide scientists with the information necessary to develop treatments to target stored HIV versions on FDCs. "If we could go in and perhaps flush it from the surface of the cell, we might decrease dramatically the amount of virus that could perpetuate infection," Burton said.
The researchers added that it is possible that potential treatments derived from the research could be used to treat other conditions, such as allergy and autoimmune disease. The researchers are applying for an NIH grant to develop a way to attack HIV stored in FDCs, according to the Morning News (Collins, Deseret Morning News, 5/13). 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。
Researchers at Brigham Young University and the Johns Hopkins School of Medicine have discovered a human cell "reservoir," called follicular dendritic cells, that allows HIV to stay in an infectious state and not respond to antiretroviral drugs, the Deseret Morning News reports. The research, which was funded by NIH and the American Foundation for AIDS Research, will be published in the June issue of the Journal of Virology.
底沙雷特早报：杨百翰大学和约翰-霍布金斯大学医学院的研究员声称发现了一种叫做滤泡树突细胞（FDCs）的“细胞储存库”，这种细胞可以使HIV保持其传染性但免于抗病毒药的杀伤。由国立卫生研究院和美国爱滋研究基金会赞助的这项研究将会发表在6月份的《病毒学报》杂志上。
According to the Morning News, researchers have long believed that there are reservoirs in the body that allow HIV to remain in an infectious state despite treatment. FDCs are the third reservoir to be identified. The other two reservoirs are macrophages and CD4+ T cells infected with a latent form of HIV. FDCs store material needed to maintain antibodies in the immune system and release proteins to trigger production of certain antibodies if they become low.
据底沙雷特早报说，研究员很久之前就相信机体存在一种使爱滋病毒具有传染性但免于药物杀伤的储存细胞。滤泡树突细胞（FDCs）是第三种这样的细胞，其他两种是巨噬细胞和CD4+细胞。在免疫系统，FDCs储存抗体的原料，当抗体低时又释放相关蛋白质来触发这些抗体的生产。
Greg Burton, professor of chemistry and biochemistry at BYU, and colleagues discovered FDCs by analyzing samples from HIV-positive people. The researchers discovered that FDCs, which are located in lymph nodes, trap HIV on their services. The trapped HIV does not show behavior -- such as replicating or mutating -- that is targeted by antiretrovirals and, therefore, is able to avoid the drugs, according to Burton.
杨百翰大学的化学与生物化学教授Greg Burton及其同事在分析HIV阳性病人的（体液）样本时发现了滤泡树突细胞（FDCs）。研究员发现这种定位于淋巴结的滤泡树突细胞会出于自身的功能而吞噬爱滋病毒。Bruton教授说被吞噬的病毒并不会表现出任何行为，比如复制，突变，而这些行为正是药物作用的靶点，因此，爱滋病毒可以免于被药物杀伤。
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作者:admin@医学,生命科学 2010-11-03 05:11
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