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【medical-news】前列腺癌的基因治疗
HOUSTON -- (Sept. 25, 2006) ?Researchers at Baylor College of Medicine (BCM) are hoping a new gene therapy that takes a gene called RTVP-1 directly into the prostate tumor will prove effective in preventing recurrence of the disease.
The first phase of the study is designed to test the safety of the treatment and determine the proper dosage of gene, said Dr. Dov Kadmon, professor of urology at BCM. It will be carried out in the department of urology at BCM as well as at Ben Taub General Hospital, The Methodist Hospital and Michael E. DeBakey Veterans Affairs Medical Center.
"We are treating patients who are scheduled for a prostatectomy (prostate removal) but who also have a high risk that their disease will recur (or come back)," said Kadmon. "The operation itself is highly successful in eradicating local tumors (in the prostate)."
The design of the study is simple, said Kadmon.
"One injection into the prostate that should take no more than 10 minutes, although patients will be monitored in a special unit of the hospital for 23 hours to make sure there are no side effects. After that, they come to the unit for a check-up once a week."
After about 30 days, the subjects undergo their surgery, which has already been scheduled, he said. He said the hope is that the gene therapy will reduce the risk that cancer will recur at or near the site of the tumor as well as in distant points in the body.
"We hope that by generating a systemic immune response, we are enabling the body to destroy prostate cancer cells that have moved elsewhere," he said. Kadmon and his colleagues plan to test six different doses of the gene.
The gene therapy involves attaching an inactivated adenovirus (related to viruses that cause respiratory infections) to the RTVP-1 gene. As the virus infects the tumor cells, it will introduce the gene into the cells as well. (RTVP stands for related to testes-specific, vespid and pathogenesis proteins.) The RTVP-1 gene was isolated in the laboratory of Dr. Timothy Thompson, also a professor of urology at BCM.
As Thompson began to study the gene, he found that it was a target for a tumor suppressor gene called p53, which is a major controller of cell activity in prostate and other cancers. He found that the human form of the gene is normally present in benign prostate or low grade tumor but is lost as the tumors become more malignant. "This characterized it as a tumor suppressor gene that is active in the prostate," said Kadmon.
When the gene is introduced into the tumors of animals lacking RTVP-1, it suppresses the formation of new blood vessels. It causes what is known as "apoptosis" or programmed cell death in prostate cancer cells and also activates the immune system to fight cancer cells.
"We are proceeding carefully, step-by-step," said Kadmon. He said they do not think the study presents a significant risk.
They will inject the virus-gene compound directly into the prostate. While there is a risk of infection with the injection, he said patients will receive antibiotics. Most patients will have some fever after the injection, but it can probably be handled with Tylenol.
Doctors will monitor patients after their surgery to determine the effect of the gene therapy on their disease.
Funding for the study, which will include as many as 36 subjects, comes from the National Cancer Institute and the Baylor Special Program for Research Excellence in Prostate Cancer that is NCI-funded.
Others involved in the study include Thompson, Dr. Brian J. Miles, BCM professor of urology; Dr. Adrian Gee, BCM professor of medicine and pediatrics in the section of hematology oncology; Dr. Thomas M. Wheeler, BCM professor of pathology and urology; Dr. Gustavo E. Ayala, BCM professor of pathology and urology; Dr. Martha P. Mims, BCM assistant professor of medicine in the section of hematology-oncology; and Dr. Teresa G. Hayes, BCM assistant professor of medicine, section of hematology-oncology.
Patients qualified to participate in this study are individuals diagnosed with high grade prostate cancer (Gleason grade 7 or higher), or who have a blood PSA level of 10ng/ml or higher and are contemplating surgery (radical prostatectomy). To register for the study or to obtain further information, patients may call 713-798-4895. 认领了，试试看！ 译者按：基因治疗对于许多疾病的患者是一种福音，但在目前对于大多数患者来讲，又是一个可望而不可及的空中楼阁。例如对于糖尿病特别是胰岛素依赖型糖尿病患者来讲，只是自身缺乏分泌胰岛素的能力或者所分泌的胰岛素缺乏活性，由此所带来的痛苦很多，后果相当严重，目前虽然国外已经有了可供植入的insulin pump，但由于价格昂贵不可能普及，大多数患者特别是到了后期出现严重并发症的患者生活质量还是很低的。对于癌症患者更是如此，如果能早发现早治疗还有存活的机率，一旦复发，就更加不堪设想。如果能像下文描述的那样通过基因的转入来得到根植或预防复发，那真是善莫大焉。古人云：不为良相，便为良医。期待着这些想法能够早日变成现实。 呵呵，请审阅，申请加分。 哇塞，动作真是快，我也是当天翻译好的，只不过上网不方便，发帖晚了些，竟被楼上大哥捷足先登！呵呵！看看我的翻译吧，多多指教！
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作者:admin@医学,生命科学 2011-01-26 17:14
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