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【medical-news】麻疹和HPV：增加肺癌风险
Measles, HPV Linked to Development of Lung Cancer, Study Shows
April 25, 2008 -- Smoking is by far the leading risk factor for lung cancer, but new research suggests that common viruses, including one linked to cervical cancer, may also contribute to the development of the deadly disease.
Scientists have found evidence of the measles virus and human papillomaviruses (HPV) in samples of tissue taken from lung cancer patients, according to two early studies being presented this week at the 1st European Lung Cancer Conference in Geneva, Switzerland.
Arash Rezazadeh, MD, and colleagues from the University of Louisville in Kentucky examined lung cancer tissue samples taken from 23 patients, all smokers. Six samples tested positive for HPV, although one case resulted from cervical cancer that spread to the lungs. The remaining five HPV-positive samples comprised the following strains: HPV-16, HPV-11, and HPV-22.
"The fact that five out of 22 non-small-cell lung cancer samples were HPV-positive supports the assumption that HPV contributes to the development of non-small-cell lung cancer (NSCLC)," the study authors say in a news release.
The findings raise an intriguing question: Could an HPV vaccine similar to Gardasil, the one approved to protect women against cervical cancer, also help thwart lung cancers? Rezazadeh writes in the meeting abstract that the research "has significant implication considering the new introduction of a HPV vaccine and its potential effect on developing NSCLC."
Rezazadeh's team theorizes that HPV may play a role as a co-carcinogen, which means it increases the risk of cancer among those who smoke.
For the second study, Samuel Ariad of the Soroka Medical Center in Beer Sheva, Israel, examined tissue samples from 65 patients with non-small-cell lung cancer and found that more than half of the samples tested positive for the measles virus.
"Measles virus is a ubiquitous human virus that may be involved in the pathogenesis of lung cancer," Ariad says in a news release. "Most likely, it acts in modifying the effect of other carcinogens and not as a causative factor by itself."
The American Cancer Society estimates that more than 161,000 people in the United States will die from lung cancer in 2008.
http://www.webmd.com/lung-cancer/news/20080424/common-viruses-raise-lung-cancer-risk 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Smoking is by far the leading risk factor for lung cancer, but new research suggests that common viruses, including one linked to cervical cancer, may also contribute to the development of the deadly disease.
吸烟是到目前为止肺癌的主要风险因子，但新的研究发现常见的病毒，包括一种与宫颈癌(cervical cancer)相关的病毒，可能也与这种致死性疾病的发民展有关。
Scientists have found evidence of the measles virus and human papillomaviruses (HPV) in samples of tissue taken from lung cancer patients, according to two early studies being presented this week at the 1st European Lung Cancer Conference in Geneva, Switzerland.
根据最近在瑞士，日内瓦，第一届欧洲肺癌会议上的两个早期研究结果的报道，科学家已经证实在肺癌患者的组织标本中有麻疹病毒和人乳头瘤病毒(HPV)的证据。
Arash Rezazadeh, MD, and colleagues from the University of Louisville in Kentucky examined lung cancer tissue samples taken from 23 patients, all smokers. Six samples tested positive for HPV, although one case resulted from cervical cancer that spread to the lungs. The remaining five HPV-positive samples comprised the following strains: HPV-16, HPV-11, and HPV-22.
来自 肯塔基，幕路易斯维尔大学（university of louisville） 的Arash Rezazadeh医生和他的同事，检测了23名患者的的肿瘤组织标本，他们都是烟民。其中6个标本中HPV检测阳性，虽然其中一个患者是因为宫颈癌扩散到肺。剩余的5个阳性患者有以下几种病毒类型：HPV-16, HPV-11, 和 HPV-22。
"The fact that five out of 22 non-small-cell lung cancer samples were HPV-positive supports the assumption that HPV contributes to the development of non-small-cell lung cancer (NSCLC)," the study authors say in a news release.
研究作者在消息发布会上说：“在22个NSCLC肺癌标本中有5个阳性，提示了HPV与非小细胞肺癌(NSCLC)的发生有关。”
The findings raise an intriguing question: Could an HPV vaccine similar to Gardasil, the one approved to protect women against cervical cancer, also help thwart lung cancers? Rezazadeh writes in the meeting abstract that the research "has significant implication considering the new introduction of a HPV vaccine and its potential effect on developing NSCLC."
这些发现产生了一个有趣的问题：是否已被批准用来预防女性宫颈癌的HPV疫苗，如GARDASI，也能对肺癌起预防作用？Rezazadeh 在会议的摘要中说，这个研究“提示需要考虑HPV疫苗的新作用，和它的潜在的对NSCLC发展的作用。”
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作者:admin@医学,生命科学 2010-12-10 05:11
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