主页 > 医学文档 >
【medical-news】研究发现增加Alzheimer病风险基因
Study: Gene may raise risk of Alzheimer's
NEW YORK -- A huge international study has identified a gene that apparently can raise the risk of developing the most common form of Alzheimer's disease, a discovery that may help scientists develop new treatments.
Scientists analyzed DNA from more than 6,000 people from a variety of ethnic groups and found evidence implicating certain versions of the gene, called SORL1.
It's too soon to tell how much those gene versions raise the risk of getting Alzheimer's or what percentage of cases they account for, the researchers said. They said the effect on risk appears to be modest.
Still, if the finding is confirmed by other scientists, it would be "a very substantial step forward in our understanding of the genetics of Alzheimer's disease," said one expert not involved in the work, Jonathan Haines of Vanderbilt University.
By shedding light on the biology of the illness, the discovery could help lead scientists to find new treatments, he and other experts said.
Up to 4.5 million Americans are estimated to have Alzheimer's, which gradually destroys memory and other mental abilities.
The study, released on the Web site of the journal Nature Genetics, focused on Alzheimer's that appears after age 65, the most common type.
Only one gene, called APOE, has been firmly linked to raising susceptibility to the common form. A Harvard-based group lists about 20 other genes it considers promising candidates, based on research. Some authors of the new paper said they believe the evidence for SORL1 is unusually strong.
Experts familiar with the new work said SORL1 probably is involved in Alzheimer's but cautioned that it will be important for other scientists to confirm that.
"People will jump on it pretty fast," said Rudy Tanzi of Harvard Medical School.
Gerard Schellenberg of the University of Washington said the paper's evidence is "pretty solid, so I'm optimistic that it will be replicated."
Dr. Sam Gandy, a researcher who chairs the medical and scientific advisory council of the Alzheimer's Association, which helped finance the new study, said he doubted SORL1 or any other gene plays as big a role in causing the disease as APOE does. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。
Study: Gene may raise risk of Alzheimer's
研究：可增加Alzheimer风险性的基因．
NEW YORK -- A huge international study has identified a gene that apparently can raise the risk of developing the most common form of Alzheimer's disease, a discovery that may help scientists develop new treatments.
纽约－大量的国际研究证实有一种基因能明显地增加Alzheimer疾病的发生风险，这个发现可以帮助科学家开展新的治疗．
Scientists analyzed DNA from more than 6,000 people from a variety of ethnic groups and found evidence implicating certain versions of the gene, called SORL1.
科学家分析了来自各种族的超过6000认得DNA，发现关于基因复杂肯定的证据，就是SORL1．
It's too soon to tell how much those gene versions raise the risk of getting Alzheimer's or what percentage of cases they account for, the researchers said. They said the effect on risk appears to be modest.
这些基因对得Alzheimer风险的提高有多大作用，以及有多少病例是因此引起的，现在说还为时过早．他们说风险的影响显示不明显．
Still, if the finding is confirmed by other scientists, it would be "a very substantial step forward in our understanding of the genetics of Alzheimer 's disease," said one expert not involved in the work, Jonathan Haines of Vanderbilt University.
至今为止，如果这个发现被其它科学家证明，这将会是对Alzheimer疾病基因研究的以个实质性进步，美国公民健康与事故保险的一个专家认为，他并没有参与该工作．
By shedding light on the biology of the illness, the discovery could help lead scientists to find new treatments, he and other experts said.
通过对疾病生物学研究的进展，这个发现将会有助于引导科学家发现新的治疗措施，他和其它专家认为．
Up to 4.5 million Americans are estimated to have Alzheimer's, which gradually destroys memory and other mental abilities.
约有4百50万美国人估计患有Alzheimer病，这会摧毁记忆和其它心理能力．
The study, released on the Web site of the journal Nature Genetics, focused on Alzheimer's that appears after age 65, the most common type.
该关于Alzheimer的研究在国家基因杂志的网站上，Alzheimer病通常在65岁之后出现．
Only one gene, called APOE, has been firmly linked to raising susceptibility to the common form.
只有一个叫APOE的基因被证实与通常形式的易感性升高有关．
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-09-07 17:12
医学,生命科学网