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【medical-news】维持清醒药物不能滥用：小心致命
Life-Threatening Skin Rash, Psychiatric Symptoms Now Noted on Drug's Label
Oct. 24, 2007 -- Provigil, a prescription stay-awake drug, is getting new warnings about the risk of life-threatening rash, other serious hypersensitivity reactions, and psychiatric symptoms.
Provigil is used to promote wakefulness in adults with conditions involving excessive sleepiness, including narcolepsy.
At least one person died of multi-organ failure shortly after starting Provigil, and there have been "rare" cases of serious or life-threatening rash in patients taking Provigil, states the drug's maker, Cephalon Inc.
The FDA and Cephalon advise patients to immediately stop Provigil and call a doctor if they have rash or other hypersensitivity reactions including:
Swelling of the face, eyes, lips, tongue, or larynx
Difficulty swallowing or breathing
Hoarseness
Harmless rashes can also occur in patients taking Provigil. But it's "not possible to reliably predict which rashes will prove to be serious," so patients should stop Provigil at the first sign of rash, unless the rash is "clearly not drug-related," states Cephalon.
Psychiatric symptoms including anxiety, mania, hallucinations, and suicidal thinking have also been reported in patients taking Provigil.
Doctors should be cautious about giving Provigil to patients with a history of psychosis, depression, or mania, states Cephalon.
Cephalon recommends that doctors should consider stopping Provigil in patients who develop psychiatric symptoms.
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提神药物Provigil新警讯
Life-Threatening Skin Rash, Psychiatric Symptoms Now Noted on Drug's Label
药物标签新增致命性皮疹、精神症状
Oct. 24, 2007 -- Provigil, a prescription stay-awake drug, is getting new warnings about the risk of life-threatening rash, other serious hypersensitivity reactions, and psychiatric symptoms.
2007年10月24日报道，处方提神药物Provigil新增有关致命皮疹、严重超敏反应以及精神症状等警语。
Provigil is used to promote wakefulness in adults with conditions involving excessive sleepiness, including narcolepsy.
At least one person died of multi-organ failure shortly after starting Provigil, and there have been "rare" cases of serious or life-threatening rash in patients taking Provigil, states the drug's maker, Cephalon Inc.
Provigil用于促进嗜睡、包括发作生睡眠症的成人清醒。
该药制造商Cephalon药厂表示，至少有一位患者在服用Provigil后不久即死于多脏器衰竭，还有一些罕见案例如严重或致命性皮疹。
The FDA and Cephalon advise patients to immediately stop Provigil and call a doctor if they have rash or other hypersensitivity reactions including:
Swelling of the face, eyes, lips, tongue, or larynx
Difficulty swallowing or breathing
Hoarseness
美国食品药物管理局(FDA)和Cephalon药厂建议，患者在出现皮疹或者以下超敏反应时立即立即停用Provigil并就诊： 面部、眼、唇、舌或咽喉肿胀；吞咽或呼吸困难；声音嘶哑。
Harmless rashes can also occur in patients taking Provigil. But it's "not possible to reliably predict which rashes will prove to be serious," so patients should stop Provigil at the first sign of rash, unless the rash is "clearly not drug-related," states Cephalon.
服用Provigil的患者也可能出现无害皮疹，但Cephalon药厂表示，因无法有效预测哪些皮疹是严重型，所以患者一旦出现皮疹应立即停用Provigil，除非能够确定皮与药物无关。
Psychiatric symptoms including anxiety, mania, hallucinations, and suicidal thinking have also been reported in patients taking Provigil.
服用Provigil患者出现的精神症状包括焦虑、狂燥、幻觉，以及自杀想法。
Doctors should be cautious about giving Provigil to patients with a history of psychosis, depression, or mania, states Cephalon.
Cephalon recommends that doctors should consider stopping Provigil in patients who develop psychiatric symptoms.
Cephalon药厂提醒，医师为有精神病、忧郁或燥症病史的患者开Provigil处方时必须谨慎。
Cephalon药厂建议，当患者出现精神症状时，医师必须考虑停用Provigil。
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编译
提神药物Provigil新警讯
Provigil药物标签新增有关致命皮疹、严重超敏反应以及精神症状等警语。
Provigil是一种处方提神药物，用于促进嗜睡的成人清醒。
该药制造商Cephalon药厂称，至少有一位患者在服用Provigil后不久即死于多脏器衰竭，还有一些罕见案例如严重或致命性皮疹。精神症状包括焦虑、狂燥、幻觉，以及自杀想法。
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作者:admin@医学,生命科学 2011-04-30 17:11
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