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【medical-news】化学＂染料＂帮助外科医生确认肿
Chemical 'Paint' Helps Surgeons See Cancer's Borders
Removing all of the tumor is key to preventing recurrence, researchers say
MONDAY, July 16 (HealthDay News) -- Researchers say they've developed a tumor "paint" that illuminates cancerous cells and help surgeons spot the borders of tumors.
A team at Seattle Children's Hospital Research Institute and the Fred Hutchinson Cancer Research Center found that the paint -- a protein derived from scorpions called chlorotoxin -- helped surgeons distinguish between brain tumor cells and normal brain tissue during surgery.
"My greatest hope is that tumor paint will fundamentally improve cancer therapy. By allowing surgeons to see cancer that would be undetectable by other means, we can give our patients better outcomes," study senior author Dr. James M. Olson said in a prepared statement.
The findings are in the July 15 issue of the journal Cancer Research.
Chlorotoxin is linked to a molecular "beacon" called Cy5.5. The use of chlorotoxin:Cy5.5 improves the likelihood that surgeons will be able to remove all cancerous cells during surgery without damaging surrounding healthy tissue, the researchers said. This is especially important for brain cancer patients. About 80 percent of malignant cancers recur at the edges of sites where tumors have been surgically removed.
Until now, there has been no way to allow surgeons to "see" tumors during surgery.
The researchers also noted that current technology, such as MRI, can distinguish tumors from healthy tissue only if more than one million cancer cells are present. Chlorotoxin:Cy5.5 is able to identify tumors with as few as 200 cancer cells, which means that it's 500 times more sensitive than MRI.
The tumor paint has been successfully tested in mice, and pilot safety trials have been completed. The researchers are preparing required toxicity studies before they apply to the U.S. Food and Drug Administration for permission to begin human clinical trials with the tumor paint. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Chemical 'Paint' Helps Surgeons See Cancer's Borders
Removing all of the tumor is key to preventing recurrence, researchers say
化学"染料"帮助外科医生确认肿瘤边缘
研究人员称，切除全部肿瘤是预防复发的关键所在
MONDAY, July 16 (HealthDay News) -- Researchers say they've developed a tumor "paint" that illuminates cancerous cells and help surgeons spot the borders of tumors.
研究人员称，他们开发了一种能够使肿瘤细胞发光的肿瘤“染料”，可帮助外科医生确认肿瘤边缘。
A team at Seattle Children's Hospital Research Institute and the Fred Hutchinson Cancer Research Center found that the paint -- a protein derived from scorpions called chlorotoxin -- helped surgeons distinguish between brain tumor cells and normal brain tissue during surgery.
西雅图儿童医院研究所和Fred Hutchinson癌症研究中心的研究小组发现，该染料能够帮助外科医生在手术时区分大脑肿瘤和正常大脑组织。该染料被成为氯毒素，是一种来源于蝎毒的蛋白成分。
"My greatest hope is that tumor paint will fundamentally improve cancer therapy. By allowing surgeons to see cancer that would be undetectable by other means, we can give our patients better outcomes," study senior author Dr. James M. Olson said in a prepared statement.
“我最大的希望是这种肿瘤染料将从根本上促进癌症的治疗。一旦外科医生看见其它方法不能检测到的癌细胞，则能够给病人带来更好的治疗效果。”该项目负责人James M. Olson医生在书面声明中说道。
The findings are in the July 15 issue of the journal Cancer Research.
该发现发表在7月15日出版的《癌症研究》杂志上。
Chlorotoxin is linked to a molecular "beacon" called Cy5.5. The use of chlorotoxin:Cy5.5 improves the likelihood that surgeons will be able to remove all cancerous cells during surgery without damaging surrounding healthy tissue, the researchers said. This is especially important for brain cancer patients. About 80 percent of malignant cancers recur at the edges of sites where tumors have been surgically removed.
氯毒素与一种荧光指示剂Cy5.5相结合，外科医生在手术时应用氯毒素:Cy5.5，将能够切除全部癌边细胞而不损伤周围正常组织。这对于脑瘤患者尤为重要。约80%的恶性肿瘤的手术切除部位边缘复发。
Until now, there has been no way to allow surgeons to "see" tumors during surgery.
迄今，外科医生在手术期间没有办法“认定”肿瘤。
The researchers also noted that current technology, such as MRI, can distinguish tumors from healthy tissue only if more than one million cancer cells are present. Chlorotoxin:Cy5.5 is able to identify tumors with as few as 200 cancer cells, which means that it's 500 times more sensitive than MRI.
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作者:admin@医学,生命科学 2011-02-15 17:12
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