主页 > 医学讨论 >
【NEJM】硫酸镁可减少脑性麻痹
硫酸镁可能减少 脑瘫
Using Magnesium Sulfate to Stop Preterm Labor May Lessen the Chance of Moderate to Severe Cerebral Palsy
用硫酸镁阻止早产可能减少 中等到重度脑瘫的机率
Aug. 27, 2008 -- Stopping preterm labor with magnesium sulfate may lessen a child's chances of later being diagnosed with moderate to severe cerebral palsy.
Aug. 27, 2008 -- 用硫酸镁阻止早产可能减少 （出生后）婴儿患中等到重度脑瘫
That news, published in The New England Journal of Medicine, comes from a study of women 24-31 weeks pregnant and at imminent risk of giving birth prematurely origin paper:
http://content.nejm.org/cgi/content/short/359/9/895
A Randomized, Controlled Trial of Magnesium Sulfate for the Prevention of Cerebral Palsy
ABSTRACT
Background Research suggests that fetal exposure to magnesium sulfate before preterm birth might reduce the risk of cerebral palsy.
Methods In this multicenter, placebo-controlled, double-blind trial, we randomly assigned women at imminent risk for delivery between 24 and 31 weeks of gestation to receive magnesium sulfate, administered intravenously as a 6-g bolus followed by a constant infusion of 2 g per hour, or matching placebo. The primary outcome was the composite of stillbirth or infant death by 1 year of corrected age or moderate or severe cerebral palsy at or beyond 2 years of corrected age.
Results A total of 2241 women underwent randomization. The baseline characteristics were similar in the two groups. Follow-up was achieved for 95.6% of the children. The rate of the primary outcome was not significantly different in the magnesium sulfate group and the placebo group (11.3% and 11.7%, respectively; relative risk, 0.97; 95% confidence interval [CI], 0.77 to 1.23). However, in a prespecified secondary analysis, moderate or severe cerebral palsy occurred significantly less frequently in the magnesium sulfate group (1.9% vs. 3.5%; relative risk, 0.55; 95% CI, 0.32 to 0.95). The risk of death did not differ significantly between the groups (9.5% vs. 8.5%; relative risk, 1.12; 95% CI, 0.85 to 1.47). No woman had a life-threatening event.
Conclusions Fetal exposure to magnesium sulfate before anticipated early preterm delivery did not reduce the combined risk of moderate or severe cerebral palsy or death, although the rate of cerebral palsy was reduced among survivors. (ClinicalTrials.gov number, NCT00014989 [ClinicalTrials.gov] .)
请注意原文章的结论是：
Fetal exposure to magnesium sulfate before anticipated early preterm delivery did not reduce the combined risk of moderate or severe cerebral palsy or death, although the rate of cerebral palsy was reduced among survivors.[标签:content1][标签:content2]
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-09-01 05:11
医学,生命科学网