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【medical-news】为何胰岛素可加速伤口愈合?
Why Applying Insulin To Wounds Significantly Enhances Healing
Insulin is a hormone known primarily for regulating sugar levels in the blood, yet researchers at the University of California, Riverside, recently found that applying insulin directly to skin wounds significantly enhanced the healing process.
Skin wounds in rats treated topically with insulin healed faster"surface cells in the epidermis covered the wound more quickly and cells in the dermis, the deeper part of the skin, were faster in rebuilding blood vessels.
In follow-up studies of human skin cells in culture, Manuela Martins-Green and colleagues explored the molecular impact of topical insulin on keratinocytes, the cells that regenerate the epidermis after wounding, and on microvascular endothelial cells, the cells that restore blood flow.
Using various cell and molecular techniques, the researchers discovered that insulin stimulates human keratinocytes in culture to proliferate and migrate. In cultured human microvascular endothelial cells, the insulin stimulates only migration into the wound tissue. The insulin works by switching on cellular signaling proteins called kinases (specifically Src, PI3K, and Akt) and a protein (SREBP) that binds elements in DNA that regulate the production of cholesterol and its relatives.
Chronic or nonhealing wounds take an immense toll on American health and on health care systems. It particularly affects millions of patients with impaired mobility, as well as those with diabetes. Because diabetes is a disease caused by impaired production or utilization of insulin, this work may help explain the connection between diabetes and poor healing.
Says Martins-Green, "This work is important because when we know which cells respond to insulin and which molecules are involved, we may be able to develop ways in which we can make insulin work even better or find ways in which more affordable molecules that mimic these functions of insulin can be developed to treat people who suffer from poor healing." 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Why Applying Insulin To Wounds Significantly Enhances Healing
为何胰岛素可加速伤口愈合?
Insulin is a hormone known primarily for regulating sugar levels in the blood, yet researchers at the University of California, Riverside, recently found that applying insulin directly to skin wounds significantly enhanced the healing process.
胰岛素作为调控血糖的激素而知名，但加利福尼亚大学河滨分校的研究者最近发现在伤口涂布胰岛素能加快其愈合。
Skin wounds in rats treated topically with insulin healed faster"surface cells in the epidermis covered the wound more quickly and cells in the dermis, the deeper part of the skin, were faster in rebuilding blood vessels.
局部应用了胰岛素的小鼠皮肤伤口愈合加快，表现在上皮细胞更快地覆盖伤口，而且处于皮肤更深层的真皮加快了血管的重建。
In follow-up studies of human skin cells in culture, Manuela Martins-Green and colleagues explored the molecular impact of topical insulin on keratinocytes, the cells that regenerate the epidermis after wounding, and on microvascular endothelial cells, the cells that restore blood flow.
在接下来对人皮肤细胞培养的研究中，Manuela Martins-Green和他的同事探究了局部应用胰岛素对角质化细胞和微血管内皮细胞的影响。角质化细胞能使伤口上皮再生，而微血管内皮细胞能重建伤口血供。
Using various cell and molecular techniques, the researchers discovered that insulin stimulates human keratinocytes in culture to proliferate and migrate. In cultured human microvascular endothelial cells, the insulin stimulates only migration into the wound tissue. The insulin works by switching on cellular signaling proteins called kinases (specifically Src, PI3K, and Akt) and a protein (SREBP) that binds elements in DNA that regulate the production of cholesterol and its relatives.
应用不同的细胞和分子技术，研究者发现胰岛素刺激人类的角质化细胞增殖和移行和微血管内皮细胞向伤口组织移行。胰岛素通过激活细胞信号蛋白——激酶（特别是Src, PI3K,和Akt）和一种DNA结合因子而发挥其作用，而这种DNA结合因子能调整胆固醇和其类似物的生产。
Chronic or nonhealing wounds take an immense toll on American health and on health care systems. It particularly affects millions of patients with impaired mobility, as well as those with diabetes. Because diabetes is a disease caused by impaired production or utilization of insulin, this work may help explain the connection between diabetes and poor healing.
慢性伤口或不愈合伤口在美国的健康和卫生保健系统中花费巨大，那些罹患移动阻碍和糖尿病的病人更是深受影响，因为糖尿病是由于产生或利用胰岛素障碍引起的，这项工作也许能解释为何糖尿病病人的伤口难以愈合。
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作者:admin@医学,生命科学 2011-05-02 05:14
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