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【文摘发布】糖尿病治疗新视点：胃肠道激素与
Author：Maggs D, Macdonald I, Nauck MA.
Resource: Diabetes Obes Metab. 2007 May 8; [Epub ahead of print]
Abstract：
The gastrointestinal tract is increasingly viewed as a critical organ in glucose metabolism because of its role in delivering glucose to the circulation and in secreting multiple glucoregulatory hormones that, in concert with insulin and glucagon, regulate glucose homeostasis. Under normal conditions, a complex interplay of these hormones acts to maintain plasma glucose within a narrow range despite large variations in the availability of glucose, particularly during transition from the fasting to fed state. In the fed state, the rate at which nutrients are passed from the stomach to the duodenum, termed gastric emptying rate, is a key determinant of postprandial glucose flux. In patients with diabetes, the regulation of glucose metabolism is disrupted resulting in fasting and postprandial hyperglycaemia. Elucidation of the role of the gastrointestinal tract, gut-derived glucoregulatory peptides and gastric emptying rate offers a new perspective on glucose homeostasis and the respective importance of these factors in the diabetes state. This review will highlight the importance of the gastrointestinal tract in playing a key role in glucose homeostasis, particularly in the postprandial period, and the role of established or new therapies that either leverage or modify gastrointestinal function to improve glycaemic state.
PMID: 17490426
Fulltext links：http://www.blackwell-synergy.com/doi/abs/10.1111/j.1463-1326.2007.00737.x 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 Title：Glucose homeostasis and the gastrointestinal tract: insights into the treatment of diabetes.
题目：糖尿病治疗的新视点：血糖调节和胃肠道
Author：Maggs D, Macdonald I, Nauck MA.
Resource: Diabetes Obes Metab. 2007 May 8; [Epub ahead of print]
来源：糖尿病、肥胖症和新陈代谢 2007年5月8日
Abstract：
摘要
The gastrointestinal tract is increasingly viewed as a critical organ in glucose metabolism because of its role in delivering glucose to the circulation and in secreting multiple glucoregulatory hormones that, in concert with insulin and glucagon, regulate glucose homeostasis. Under normal conditions, a complex interplay of these hormones acts to maintain plasma glucose within a narrow range despite large variations in the availability of glucose, particularly during transition from the fasting to fed state. In the fed state, the rate at which nutrients are passed from the stomach to the duodenum, termed gastric emptying rate, is a key determinant of postprandial glucose flux. In patients with diabetes, the regulation of glucose metabolism is disrupted resulting in fasting and postprandial hyperglycaemia. Elucidation of the role of the gastrointestinal tract, gut-derived glucoregulatory peptides and gastric emptying rate offers a new perspective on glucose homeostasis and the respective importance of these factors in the diabetes state. This review will highlight the importance of the gastrointestinal tract in playing a key role in glucose homeostasis, particularly in the postprandial period, and the role of established or new therapies that either leverage or modify gastrointestinal function to improve glycaemic state
“在糖代谢方面，胃肠道是重要调节器官”这一观点被逐渐认同，它可吸收葡萄糖入血和分泌多种血糖调节激素，与胰岛素和胰高血糖素共同协调，维持血糖的稳定。在正常条件下，尽管可用葡萄糖有大幅度变化（特别在人体从禁食转为进食状态），但这些激素间复杂的相互作用仍可维持血糖在小范围波动。在进食状态下，食物从胃到十二指肠的通过速率，简称胃排空速率，是餐后葡萄糖流量关键决定因子。糖代谢调节机制失调导致糖尿病患者禁食低血糖、餐后高血糖。对胃肠道，肠源性血糖调节肽和胃排空速率作用的认识有利于加深我们对血糖调节和他们各自对糖尿病作用的认识。本综述重点阐述胃肠道在血糖调节中扮演的重要角色（特别在餐后期）和传统疗法或新疗法（利用杠杆原理或修正胃肠道功能）在改善高血糖状态的作用。
PMID: 17490426
编译：中文字数（407）
2007年5月8日在《糖尿病、肥胖症和新陈代谢》杂志发表了一篇题为“糖尿病治疗的新视点：血糖调节和胃肠道”综述性文章。作者为美国学者Maggs D。
“在糖代谢方面，胃肠道是重要调节器官”这一观点被逐渐认同，它可吸收葡萄糖入血和分泌多种血糖调节激素，与胰岛素和胰高血糖素共同协调，维持血糖的稳定。在正常条件下，尽管可用葡萄糖有大幅度变化（特别在人体从禁食转为进食状态），但这些激素间复杂的相互作用仍可维持血糖在小范围波动。在进食状态下，食物从胃到十二指肠的通过速率，简称胃排空速率，是餐后葡萄糖流量关键决定因子。糖代谢调节机制失调导致糖尿病患者禁食低血糖、餐后高血糖。对胃肠道，肠源性血糖调节肽和胃排空速率作用的认识有利于加深我们对血糖调节和他们各自对糖尿病作用的认识。本综述重点阐述胃肠道在血糖调节中扮演的重要角色（特别在餐后期）和传统疗法或新疗法（利用杠杆原理或修正胃肠道功能）在改善高血糖状态的作用。 太好了，不断的更新知识，谢谢各位老师！ 胃空速率似乎翻译为胃排空速率更贴切一些。 听说有家医院在开展“胃切除”治疗“2型糖尿病”，并且现在在开推广培训？ 人们已经渐渐认识到胃肠道是重要的糖代谢调节器官。胃肠道吸收葡萄糖入血并通过分泌多种血糖调节激素，与胰岛素和胰高血糖素共同协调，维持血糖稳定。在正常条件下，这些激素间复杂的相互作用使血糖维持在小范围，即使葡萄糖有大幅度变化（特别在人体从禁食转为进食状态）。进食时，食物从胃到十二指肠的通过速率，即胃排空速率，是餐后葡萄糖流量的关键决定因子。对于糖尿病患者，由于糖代谢调节机制失调导致禁食和餐后高血糖。
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作者:admin@医学,生命科学 2011-04-29 14:38
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