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【medical-news】出生前X线暴露不增加儿童脑瘤总体
NEW YORK (Reuters Health) Dec 28 - Prenatal exposure to diagnostic X-rays does not increase the overall risk of childhood brain tumors, a Swedish research team reports. However, abdominal radiography may lead to a higher incidence of primitive neuroectodermal tumor (PNET).
Pediatric brain tumor incidence increased annually between 1973 and 1992 in Sweden, authors of the report note in the November 27th British Journal of Cancer.
To examine the role of prenatal X-rays, Dr. Karin Stalberg and colleagues accessed national registries to identify 512 children born between 1975 and 1984 diagnosed with brain tumors at less than 15 years of age, and 524 age- and gender-matched controls.
According to prospectively recorded data in antenatal medical records, 21% of mothers underwent diagnostic radiography. For abdominal X-rays, performed primarily in the third trimester, the exposure frequencies were 10.7% among cases and 9.4% among controls.
Dr. Stalberg, at Uppsala University, and her team observed no overall increased risk for childhood brain tumor after prenatal abdominal or nonabdominal X-ray exposure.
Among histological subtypes, only PNET (n = 105) was associated with abdominal X-ray exposure (adjusted odds ratio, 1.88), although the association was not statistically significant. Nonabdominal X-rays had no effect.
Prenatal exposure was not associated with risk of high- or low-grade astrocytoma, ependymoma, germ cell tumor, or other rare or incompletely specified tumors.
"Our most important finding might not be the clinical implication, but in relation to the theory that prenatal or neonatal radiation might affect the various neural cell types differently," Dr. Stalberg's team writes.
The investigators note that PTEN is classified as an embryonic tumor, believed to arise from undifferentiated neural stem cells.
They propose that "neural stem cells could be extra sensitive during their differentiation," and that radiation-induced DNA damage "could initiate malignant transformation, leading to the development of embryonic CNS tumors such as PNET."
Br J Cancer 2007;97:1583-1587.
http://www.medscape.com/viewarticle/568058 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 粗译：
Prenatal Radiography Does Not Increase Risk of Childhood Brain Tumors
生前放射线照射（孕妇孕期照射）不增加儿童时期脑肿瘤风险（不增加儿童脑癌风险）
NEW YORK (Reuters Health) Dec 28 - Prenatal exposure to diagnostic X-rays does not increase the overall risk of childhood brain tumors, a Swedish research team reports. However, abdominal radiography may lead to a higher incidence of primitive neuroectodermal tumor (PNET).
纽约（路透社健康新闻）12月28日消息：孕期X光检查总的说来并不增加儿童脑瘤风险，一个来自瑞士的研究小组报道说。然而，腹部放射却可能导致“原发性神经外胚层肿瘤”（PNET）发生率增高。
Pediatric brain tumor incidence increased annually between 1973 and 1992 in Sweden, authors of the report note in the November 27th British Journal of Cancer.
著者在11月27日版英国癌症杂志上报道说，73至92年间，瑞士小儿脑瘤发病率逐年增长。
To examine the role of prenatal X-rays, Dr. Karin Stalberg and colleagues accessed national registries to identify 512 children born between 1975 and 1984 diagnosed with brain tumors at less than 15 years of age, and 524 age- and gender-matched controls.
为了调查X光的作用，Karin Stalberg博士及其同事们使用了国家注册系统，确定了生于75至84年间而在15岁以前就被诊为脑肿瘤的共计512名儿童(作为研究人群)。同时还有524名年龄与性别都与之匹配的儿童作为对照组研究。
According to prospectively recorded data in antenatal medical records, 21% of mothers underwent diagnostic radiography. For abdominal X-rays, performed primarily in the third trimester, the exposure frequencies were 10.7% among cases and 9.4% among controls.
出生前前瞻性记录的医疗数据显示,21%的母亲接受过诊断性发射线照射。腹部X光主要在孕9月左右进行，暴露人数在研究组为10.7%，对照组为9.4%。
Dr. Stalberg, at Uppsala University, and her team observed no overall increased risk for childhood brain tumor after prenatal abdominal or nonabdominal X-ray exposure.
阿帕萨拉大学的Stalberg博士及其研究小组观察到，总的看来，出生前接受腹部或非腹部X光照射并不增加儿童脑肿瘤的罹患风险。
Among histological subtypes, only PNET (n = 105) was associated with abdominal X-ray exposure (adjusted odds ratio, 1.88), although the association was not statistically significant. Nonabdominal X-rays had no effect.
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作者:admin@医学,生命科学 2011-10-14 17:18
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