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【medical-news】绝经后妇女可通过规律锻炼及控制
Contact: Dean Forbes
dforbes@fhcrc.org
206-667-2896
Fred Hutchinson Cancer Research Center
Regular exercise, keeping weight in check reduces breast-cancer risk in postmenopausal women
SEATTLE--Postmenopausal women who want to significantly decrease their breast-cancer risk would be wise to exercise regularly and keep their weight within a normal range for their height, according to new findings from the Women's Health Initiative to be published in the journal Obesity.
The multicenter team of researchers, led by Anne McTiernan, M.D., Ph.D., of Fred Hutchinson Cancer Research Center, found that women who had the lowest body-mass index, or BMI, and the highest physical-activity levels had the lowest levels of circulating estrogens, sex hormones that can fuel breast-cancer growth.
Specifically, they found a significant decrease in the two most common, biologically active forms of estrogen, estrone and estradiol, among the most active, lean women studied. The researchers found that women with high BMI and low physical-activity had mean estrogen concentrations that were 50 percent to 100 percent higher than that of women with low BMI and high activity levels.
"Women with high levels of estrogens have a two-to-four-times-higher risk of breast cancer than women with very low levels," said McTiernan, a member of the Hutchinson Center's Public Health Sciences Division and co-investigator of the Women's Health Initiative Clinical Coordinating Center, which is based at the Center. "If a woman can keep her own natural estrogens lower after menopause, it is probably going to be beneficial in terms of reducing her risk of breast cancer."
The study, based on a random sample of 267 postmenopausal women nationwide selected from the WHI Dietary Modification Trial, is the first of its kind to examine the dual impact of body weight and physical activity on levels of various circulating sex hormones thought to impact cancer risk.
"Other studies have looked at the impact of body weight by itself or physical activity by itself but this is the first to look at both together regarding their influence on hormone levels," McTiernan said. "This gives us a new understanding that combining weight control with high levels of physical activity is necessary for keeping estrogens at a healthy level in postmenopausal women." Exercising vigorously for 30 to 60 minutes a day, five days a week would achieve this benefit, McTiernan said.
http://www.eurekalert.org/bysubject/medicine.php 我的，认领了，呵呵。
有规律的运动，保持体重可以保护绝经后的老年女性远离乳腺癌
西雅图－－据一项即将发表在《肥胖》杂志上的新的研究结果报导：绝经后的老年女性如果想要降低罹患乳腺癌的风险，就需要做到一下两点：第一坚持有规律的运动，第二就是把她们的体重保持在一个合理的范围内。
这项多个中心合作的研究是由弗雷德.哈钦森癌症研究中心的Anne McTiernan博士领导开展的，研究结果表明：体重指数最低且运动能力最强的老年女性其血液中雌激素水平最低，而雌激素是可以促进乳腺癌病灶生长的重要因素。
尤其值得注意的是，他们发现在运动最多的体形纤瘦的老年女性体内雌激素的两种生物活性形式－－雌固酮与雌二醇水平显著下降，反之体形肥胖而又缺乏锻炼者其体内雌激素水平要高出前者50％甚而100％。
来自弗雷德.哈钦森癌症研究中心健康科学部的McTiernan说：“如果女性体内雌激素水平较高的话，她罹患乳腺癌的机率将会是低雌激素者的2到4倍；一个老年女性只要在绝经后能够把体内雌激素控制在较低水平，就可以远离乳腺癌的威胁。”
这项研究的267名老年绝经女性是从全国范围内挑选的，本是参加由妇女健康组织发起的食谱修正实验的。本研究是第一项检验体重与运动这两个因素如何通过影响体内雌激素的水平进而影响受试者罹患乳腺癌的可能性的研究。
McTiernan说：“既往已有研究观察了控制体重或者提高运动能力对于激素水平的影响，而我们则是第一次把这两个因素一起纳入一项研究之中，这使我们对此二者的联合效应有了新的见解，也就是对于绝经后的老年女性而言，保持体形，积极运动对于控制雌激素水平都是必须的。每周五次，每次进行20到30分钟积极的运动就可以收到很好的效果。
积极运动，保持体形，远离乳腺癌
西雅图－－据一项即将发表在《肥胖》杂志上的新的研究结果报导：绝经后的老年女性如果想要降低罹患乳腺癌的风险，就需要做到一下两点：第一坚持有规律的运动，第二就是把她们的体重保持在一个合理的范围内。
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作者:admin@医学,生命科学 2011-09-18 05:17
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