主页 > 医学前沿 >
【medical-news】过度超重可增加静脉血栓栓塞再发
Excess body weight is a recognized risk factor for VTE, the authors explain, but it has been unclear whether excess body weight increases the risk for recurrence.
Dr. Sabine Eichinger from the Medical University of Vienna, Austria and colleagues assessed the relationship between excess body weight and symptomatic recurrent VTE in 1107 patients who were prospectively observed after their first unprovoked VTE. Patients entered the study when their anticoagulation therapy was withdrawn.
Mean body-mass index (BMI) was significantly higher in patients who experienced recurrent VTE (28.5) than in those without a recurrence (26.9, p=0.01), the authors report.
They add that excess weight and recurrence were linearly related. The adjusted hazard ratio for each 1-point increase in BMI was 1.044.
The probability of recurrent VTE at 4 years was 9.3% among normal-weight patients, 16.7% among overweight patients, and 17.5% among obese patients, the researchers note.
If all the patients had been of normal weight, the investigators say, the risk of recurrence would be 26.8% lower than the actual rate observed in this group.
"Health care professionals should be encouraged to emphasize the need for weight control when counseling overweight or obese patients with thrombosis," the authors conclude.
They add, "Since the association between excess body weight and the risk of recurrence is linear, even a small weight loss might translate into a reduction of the risk of recurrent thrombosis. Patients of normal weight who have had a thrombosis should be told that weight gain might increase their future risk of venous thrombosis."
Arch Intern Med 2008;168:1678-1683. 本人已认领本文翻译48小时若未提交请其他战友继续认领 NEW YORK (Reuters Health) Aug 28 - Excess body weight increases the risk of recurrent venous thromboembolism (VTE) after a first unprovoked venous thromboembolism, according to a report in the August 11/25 Archives of Internal Medicine.
纽约（路透社 健康）八月二十八日——据八月11/25日Internal Medicine的一篇文献报道，在罹患无明显诱因的静脉血栓栓塞症（VTE）后，过度超重增加了VTE复发的风险。
Excess body weight is a recognized risk factor for VTE, the authors explain, but it has been unclear whether excess body weight increases the risk for recurrence.
过度超重是一个已知的VTE发生的风险因子，作者解释说，但过度超重是否会增加VTE复发的风险尚不清楚。
Dr. Sabine Eichinger from the Medical University of Vienna, Austria and colleagues assessed the relationship between excess body weight and symptomatic recurrent VTE in 1107 patients who were prospectively observed after their first unprovoked VTE. Patients entered the study when their anticoagulation therapy was withdrawn.
来自奥地利维也纳医科大学的Sabine Eichinger博士和他的同事对1107名初次无诱因l罹患VTE后的患者进行前瞻性的研究，从而评估过度超重与有症状的复发性的VTE之间的关系。当患者的抗凝治疗停止后就纳入该研究中。
Mean body-mass index (BMI) was significantly higher in patients who experienced recurrent VTE (28.5) than in those without a recurrence (26.9, p=0.01), the authors report.
发现VTE复发的患者的体重指数(28.5)明显高于未有发生VTE复发患者(26.9, p=0.01)，据作者报道。
They add that excess weight and recurrence were linearly related. The adjusted hazard ratio for each 1-point increase in BMI was 1.044.
他们还发现过度超重与VTE复发呈线性相关。体重指数每升高1点其纠正后的危害比为1.044。
The probability of recurrent VTE at 4 years was 9.3% among normal-weight patients, 16.7% among overweight patients, and 17.5% among obese patients, the researchers note.
研究者特别提出，在正常体重患者其4年VTE复发的可能性为9.3%，而在超重患者为16.7%，肥胖患者为17.5%。
If all the patients had been of normal weight, the investigators say, the risk of recurrence would be 26.8% lower than the actual rate observed in this group.
如果所有的患者均为正常体重，研究者说，其复发的风险将比该组研究病人的的实际复发风险低26.8%。
"Health care professionals should be encouraged to emphasize the need for weight control when counseling overweight or obese patients with thrombosis," the authors conclude.当被咨询超重和肥胖患者与血栓形成的关系时，卫生保健专业人士应该被鼓励去强调控制体重的重要性，作者总结说。
They add, "Since the association between excess body weight and the risk of recurrence is linear, even a small weight loss might translate into a reduction of the risk of recurrent thrombosis. Patients of normal weight who have had a thrombosis should be told that weight gain might increase their future risk of venous thrombosis."
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-08-23 05:11
医学,生命科学网