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【文摘发布】准确淋巴结分期对早期和局部晚期
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TITLE:
The importance of accurate lymph node staging in early and locally advanced non-small cell lung cancer: an update on available techniques.
AUTHORS:
Kim ES, Bosquée L.
MD Anderson Cancer Center, Houston, Texas 77030-4095, USA. edkim@mdanderson.org
Medical oncologists are faced with multiple factors to consider when staging a patient with suspected or confirmed non-small cell lung cancer (NSCLC). Identifying pathological nodal (N2) disease is, however, of great importance because its presence significantly affects outcomes and potential treatment strategies. Recent data supporting the use of adjuvant or neoadjuvant therapies in these patients suggests that every reasonable effort should be made to assess the lymph node status accurately in patients with clinical early stage disease as well as in those with clinically staged N2 disease who have undergone preoperative treatments. Newer procedures such as integrated positron emission tomography computed tomography and esophageal or endobronchial endoscopic ultrasound with fine needle aspiration are minimally invasive techniques that may enhance the accuracy of mediastinal staging, traditionally devoted to mediastinoscopy. As their availability widens, they are likely to become an important part of staging and treatment paradigms. Intraoperatively, a growing body of evidence suggests that lymph node dissection can be performed safely, and should replace sampling as a more effective means of identifying unsuspected N2 disease. This paper will review the current literature on staging NSCLC with regard to the detection of nodal disease through preoperative staging of the mediastinum, the use of intraoperative lymph node sampling or dissection at the time of resection, and procedures for use in restaging patients with clinical stage IIIA N2 disease who have undergone preoperative chemotherapy (with or without radiotherapy).
PMID: 17589301 [PubMed - indexed for MEDLINE] 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 初译
J Thorac Oncol. 2007 Jun;2 Suppl 2:S59-67.
TITLE:
The importance of accurate lymph node staging in early and locally advanced non-small cell lung cancer: an update on available techniques.
早期、局限性进展型非小细胞肺癌中准确淋巴结分期的重要性：可行性技术进展
AUTHORS:
Kim ES, Bosquée L.
MD Anderson Cancer Center, Houston, Texas 77030-4095, USA. edkim@mdanderson.org
Medical oncologists are faced with multiple factors to consider when staging a patient with suspected or confirmed non-small cell lung cancer (NSCLC).
肿瘤病学家在对可疑或确诊的非小细胞肺癌患者进行分期时要面临多方面因素的考量。
Identifying pathological nodal (N2) disease is, however, of great importance because its presence significantly affects outcomes and potential treatment strategies.
然而，确诊纵隔淋巴结(N2)的病变是非常重要的，因为它会明显地影响到患者的预后和可能的治疗策略。
Recent data supporting the use of adjuvant or neoadjuvant therapies in these patients suggests that every reasonable effort should be made to assess the lymph node status accurately in patients with clinical early stage disease as well as in those with clinically staged N2 disease who have undergone preoperative treatments.
近期支持对这些患者使用辅助化疗或新辅助化疗的数据提示，对临床早期的患者和已经进行了术前治疗的临床N2期患者都要采用各种可行的方法准确评价淋巴结的状态。
Newer procedures such as integrated positron emission tomography computed tomography and esophageal or endobronchial endoscopic ultrasound with fine needle aspiration are minimally invasive techniques that may enhance the accuracy of mediastinal staging, traditionally devoted to mediastinoscopy.
最近的方法如整合PET/CT、食管内或支气管内超声内镜针刺检查是损伤性最低的技术，可以提高传统依靠纵隔镜进行分期的准确性。
As their availability widens, they are likely to become an important part of staging and treatment paradigms.
随着这些技术的广泛应用，它们有可能成为非小细胞肺癌分期和治疗模式的一部分。
Intraoperatively, a growing body of evidence suggests that lymph node dissection can be performed safely, and should replace sampling as a more effective means of identifying unsuspected N2 disease.
许多证据提示术中淋巴结清扫术可以安全的进行，而且应该替代采样淋巴结切除成为确诊可疑性N2期肿瘤更有效的方法。
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作者:admin@医学,生命科学 2011-09-17 06:36
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