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【bio-news】混合数据能够检测SNPs是否增加乳腺癌
Pooling data from numerous studies has helped scientists examine specific genetic variants related to breast cancer incidence, according to a study in the October 4 issue of the Journal of the National Cancer Institute.
The Breast Cancer Association Consortium brought together data from more than 20 groups conducting breast cancer research. Numerous studies by the collaboration's groups have identified a number of single nucleotide polymorphisms' single variations in a gene, known as SNPs, that may be linked to breast cancer.
The collaborating groups identified 16 SNPs that had been analyzed by at least three of their studies. They pooled data from all studies for each SNP and assessed how frequently the genetic change occurred in breast cancer patients compared to controls.
The authors found that five of the SNPs might be linked to breast cancer risk (with borderline statistical significance) and 11 were not. They suggest that pooling data from many groups can enable large sample sizes necessary to see associations when effects are moderate.
"This study illustrates the value of large consortia for clarifying risks associated with complex diseases," the authors write.
In an accompanying editorial, John P.A. Ioannidis, M.D., of the University of Ioannina School of Medicine in Greece, calls the study an "impressive collaborative effort." He discusses the difficulty of designing studies to accurately assess the significance of rare genetic changes. He writes, "If common genetic variants modulate susceptibility to common diseases such as breast cancer, we now have excellent tools to dissect them." 认领了 Pooled data examines if SNPs add to breast cancer risk
集中数据能够检测SNPs是否增加乳腺癌风险
Pooling data from numerous studies has helped scientists examine specific genetic variants related to breast cancer incidence, according to a study in the October 4 issue of the Journal of the National Cancer Institute.
根据国家癌症学会杂志10.4期的研究，众多研究的集中数据有助于科学家检测与乳腺癌发生率相关的特殊基因型变异。
The Breast Cancer Association Consortium brought together data from more than 20 groups conducting breast cancer research. Numerous studies by the collaboration's groups have identified a number of single nucleotide polymorphisms' single variations in a gene, known as SNPs, that may be linked to breast cancer.
乳腺癌联合协会把20多个致力于乳腺癌的研究小组的数据汇聚在一起。合作小组的众多研究已经明确了基因中许多单核苷酸多态性的单一变异，称之为SNPs，这些可能和乳腺癌相关。
The collaborating groups identified 16 SNPs that had been analyzed by at least three of their studies. They pooled data from all studies for each SNP and assessed how frequently the genetic change occurred in breast cancer patients compared to controls.
合作组确定了16个SNPs，它们已至少被三个研究小组进行过分析。他们把每个SNP的所有研究数据集中起来，通过乳腺癌患者与对照组的比较，来评价基因改变的发生频率。
The authors found that five of the SNPs might be linked to breast cancer risk (with borderline statistical significance) and 11 were not. They suggest that pooling data from many groups can enable large sample sizes necessary to see associations when effects are moderate.
作者发现这些SNPs中的5个可能与乳腺癌危险因素相关（有边缘统计学意义），另外11个没有。他们提示当效应适中的情况下，多组的集中数据有助于扩大所需的样本量。
"This study illustrates the value of large consortia for clarifying risks associated with complex diseases," the authors write.
作者写到，这个研究表明了协会的价值，它可以去阐明复杂疾病相关的危险因素。
In an accompanying editorial, John P.A. Ioannidis, M.D., of the University of Ioannina School of Medicine in Greece, calls the study an "impressive collaborative effort." He discusses the difficulty of designing studies to accurately assess the significance of rare genetic changes. He writes, "If common genetic variants modulate susceptibility to common diseases such as breast cancer, we now have excellent tools to dissect them."
在随后的评论中，希腊Ioannina大学医学院的John P.A. Ioannidis, M.D.，称这项研究有令人难忘的协作作用。他讨论了设计可准确评价稀少基因变化重要性的研究的困难性。他写到，“如果通常遗传性变型的调解对一般疾病如乳腺癌敏感，我们现在已经有很好的办法去研究它们了”。 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-08-12 05:31
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