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【bio-news】基因可能帮助一些人忍痛
Genes May Help Some People Bear Pain
THURSDAY, Oct. 26 (HealthDay News) -- People who tolerate pain better may just be blessed with better genes.
Scientists say levels of a molecule called BH4 -- required for the production of major neurotransmitter chemicals -- influence the body's sensitivity to pain.
The team of international researchers, based at Massachusetts General Hospital (MGH), Boston, say BH4 levels might also determine a person's vulnerability to chronic pain.
Reporting in the November issue of Nature Medicine, they found that a certain set of variations in a gene that's involved in producing BH4 appear to reduce a person's pain sensitivity.
"This is the first evidence of a genetic contribution to the risk of developing neuropathic pain in humans. The pain-protective gene sequence, which is carried by about 25 percent of the population, appears to be a marker both for less pain sensitivity and a reduced risk for chronic pain," study senior author Dr. Clifford Woolf, director of the Neural Plasticity Research Group at MGH, said in prepared statement.
"Identifying those at greater risk of developing chronic pain in response to medical procedures, trauma or diseases could lead to new preventive strategies and potential treatments," Woolf said.
In research involving hundreds of volunteers, the scientists concluded that people with a protective GCH1 haplotype -- a set of variations in the gene that are inherited together -- were less sensitive to pain. This GCH1 haplotype reduces production of BH4.
"Our results tell us that BH4 is a key pain-producing molecule -- when it goes up, patients experience pain, and if it is not elevated, they will have less pain," Woolf said.
"The data also suggest that individuals who say they feel less pain are not just stoics but genuinely have inherited a molecular machinery that reduces their perception of pain. The difference results not from personality or culture, but real differences in the biology of the sensory nervous system."
More information
The U.S. National Institute of Neurological Disorders and Stroke has more about pain (www.ninds.nih.gov ). 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 10月26日星期四(每日新闻)--基因可能帮助一些人忍受疼痛
科学家们说:作为主要神经递质的重要辅酶四氢生物蝶呤(BH4 )的水平影响人体疼痛的敏感性.
以哈佛大学附属麻省总医院(MGH)为基础的国际研究团队说四氢生物蝶呤(BH4 )的水平也决定人慢性疼痛的忍受程度。
据11月份的《Nature Medicine》的医学板块报道：他们发现一个负责表达BH4的基因，其某一处突变看起来能降低一个人的痛觉敏感性
任哈佛大学附属麻省总医院(MGH)的神经可塑性研究组的主管，资深研究作者 Clifford Woolf博士说：首次从遗传学角度证明了人类神经性疼痛进展的风险。25％人群携带疼痛保护性基因序列，这些基因序列被认为是疼痛敏感性及慢性疼痛风险降低的标志。
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Woolf博士说："鉴定那些医疗、创伤及疾病导致慢性疼痛发生的基因型，有助于产生新的预防策略及潜在的治疗方法。
这项研究有几百名志愿者参加，科学家得出：携带保护性GCH1基因单元型(作为一个整体遗传的多态性基因群)的人群对于疼痛是不敏感得。这个GCH1基因单元型能减少BH4得产出。
Woolf博士说："我们得结果告诉我们BH4是发生疼痛得关键分子－－当它得水平升高时病人感觉到疼痛，相反如果它的水平不上升则他们就不怎么疼痛"
数据也表明：有些人痛觉低，并不是主观因素，而是遗传分子机制使痛觉降低。痛觉差异并不是来自于个体的性格及文化背景，而是来自于感觉神经系统生物学的真正差异。
美国国立神经障碍中风研究所有更多的关于疼痛的信息。 http://www.lex18.com/Global/story.asp?S=5595786&nav=EQls
Genes May Help Some People Bear Pain
THURSDAY, Oct. 26 (HealthDay News) -- People who tolerate pain better may just be blessed with better genes.
10月26日星期四(每日新闻)--优势基因可能帮助人们更好的忍受疼痛
Scientists say levels of a molecule called BH4 -- required for the production of major neurotransmitter chemicals -- influence the body's sensitivity to pain.
科学家们说:作为主要神经递质的重要辅酶四氢生物蝶呤(BH4 )的水平影响人体疼痛的敏感性.
The team of international researchers, based at Massachusetts General Hospital (MGH), Boston, say BH4 levels might also determine a person's vulnerability to chronic pain.
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作者:admin@医学,生命科学 2011-08-12 02:19
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