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【科普】防皱化合物会引起皮肤细胞的病理反应
Public release date: 11-Apr-2007
Antiwrinkle compound causes pathological reaction in skin cells
Quebec City, April 11, 2007 -- Researchers from Universit?Laval抯 Faculty of Medicine have discovered that a compound commonly used in many antiwrinkle products causes a pathological reaction in skin cells. Guillaume Morissette, Lucie Germain, and Fran鏾is Marceau present their conclusions about the mode of action of this substance梒alled DMAE梚n the latest edition of the British Journal of Dermatology.
DMAE (2-dimethylaminoethanol) is used in many antiwrinkle products dubbed "instant anti-aging face-lifts." This compound, as well as other chemically similar ones, are also found in cosmetics, creams, lipsticks, shampoos, soaps, and baby lotions, although the way they work is not yet understood.
In vitro tests conducted by Dr. Marceau抯 team revealed that the application of DMAE induces a quick and spectacular swelling of skin cell vacuoles called fibroblasts, which act as reservoirs and interface between the inside and the outside of the cell.
In the hours following the application of DMAE, the researchers observed an important slowing down of cell division梥ometimes coming to a complete stop, the inhibition of certain metabolic reactions, and the death of a significant percentage of fibroblasts. The mortality rate of fibroblasts, which varied according to DMAE concentration, was above 25% after 24 hours in the case of a concentration similar to the one resulting from normal use of an antiwrinkle cream. The thickening of the skin induced by the pathological swelling of the fibroblasts would explain the antiwrinkle effect of DMAE, according to the researchers.
"Even though DMAE is similar to medication, there is very little scientific documentation about its pharmacological and toxicological effects," explains Dr. Marceau, who stresses his goal is not to condemn the use of this compound. "We抮e not saying DMAE is dangerous to people exposed to it, but our results indicate it抯 time to begin serious research to determine whether or not it poses a health risk."
DMAE is not a unique case in the world of beauty products, continues the researcher. "Several compounds found in cosmetics are just as complex as medication梩hey are absorbed through the skin, flow through the bloodstream, are expelled by the kidneys, or stocked in cells or even in the liver. Yet, the laws regulating their use are far less restrictive than those regulating drugs," concludes Dr. Marceau. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 Public release date: 11-Apr-2007
文章发表日期：2007年4月11日
Antiwrinkle compound causes pathological reaction in skin cells
防皱化合物会引起皮肤细胞的病理反应
Quebec City, April 11, 2007 -- Researchers from Universit?Laval抯 Faculty of Medicine have discovered that a compound commonly used in many antiwrinkle products causes a pathological reaction in skin cells. Guillaume Morissette, Lucie Germain, and Fransis Marceau present their conclusions about the mode of action of this substance called DMAE in the latest edition of the British Journal of Dermatology.
魁北克市，2007年4月11日--拉瓦尔大学医学院的研究人员已发现许多防皱产品中常用的一种化合物可以引起皮肤细胞的病态反应。Guillaume Morissette, Lucie Germain, and Fransis Marceau向最近一期的《英国皮肤病学》杂志提交了他们关于这种被称为DMAE的物质的作用方式的研究结论。
DMAE (2-dimethylaminoethanol) is used in many antiwrinkle products dubbed "instant anti-aging face-lifts." This compound, as well as other chemically similar ones, are also found in cosmetics, creams, lipsticks, shampoos, soaps, and baby lotions, although the way they work is not yet understood.
DMAE(2-二甲氨基乙醇)是被戏称为“即刻的抗老除皱剂”，用于许多抗皱产品中。这个化合物及其他化学类似物也存在于化妆品、乳膏、唇膏、洗发露、香皂、 洗剂和婴儿润肤露中， 虽然我们对它们的作用机制还不了解。
In vitro tests conducted by Dr. Marceau抯 team revealed that the application of DMAE induces a quick and spectacular swelling of skin cell vacuoles called fibroblasts, which act as reservoirs and interface between the inside and the outside of the cell.
Marceau领导的试验小组进行的体外试验发现DMAE的应用诱使皮肤细胞（成纤维细胞）空泡的迅速膨胀，皮肤细胞空泡作为细胞间的“储层水库”并衔接内外细胞。
In the hours following the application of DMAE, the researchers observed an important slowing down of cell division sometimes coming to a complete stop, the inhibition of certain metabolic reactions, and the death of a significant percentage of fibroblasts. The mortality rate of fibroblasts, which varied according to DMAE concentration, was above 25% after 24 hours in the case of a concentration similar to the one resulting from normal use of an antiwrinkle cream. The thickening of the skin induced by the pathological swelling of the fibroblasts would explain the antiwrinkle effect of DMAE, according to the researchers.
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作者:admin@医学,生命科学 2011-07-31 05:14
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