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【bio-news】脂类帮助抗争糖尿病
Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism
Haiming Cao,1 Kristin Gerhold,1,3 Jared R. Mayers,1 Michelle M. Wiest,2 Steven M. Watkins,2 and Gökhan S. Hotamisligil1,
1 Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
2 Lipomics Technologies, West Sacramento, CA 95691, USA
Corresponding author
Gökhan S. Hotamisligil
ghotamis@hsph.harvard.edu
Summary
Dysregulation of lipid metabolism in individual tissues leads to systemic disruption of insulin action and glucose metabolism. Utilizing quantitative lipidomic analyses and mice deficient in adipose tissue lipid chaperones aP2 and mal1, we explored how metabolic alterations in adipose tissue are linked to whole-body metabolism through lipid signals. A robust increase in de novo lipogenesis rendered the adipose tissue of these mice resistant to the deleterious effects of dietary lipid exposure. Systemic lipid profiling also led to identification of C16:1n7-palmitoleate as an adipose tissue-derived lipid hormone that strongly stimulates muscle insulin action and suppresses hepatosteatosis. Our data reveal a lipid-mediated endocrine network and demonstrate that adipose tissue uses lipokines such as C16:1n7-palmitoleate to communicate with distant organs and regulate systemic metabolic homeostasis. 认领，48小时内提交~ Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism
一个脂肪因子的识别，一个将脂肪组织与系统代谢联系起来的脂肪荷尔蒙
Dysregulation of lipid metabolism in individual tissues leads to systemic disruption of insulin action and glucose metabolism.
个体组织中的脂代谢紊乱会导致胰岛素作用和糖代谢系统破坏。
Utilizing quantitative lipidomic analyses and mice deficient in adipose tissue lipid chaperones aP2 and mal1, we explored how metabolic alterations in adipose tissue are linked to whole-body metabolism through lipid signals.
我们利用脂类定量分析和脂肪组织中脂质蛋白伴随蛋白aP2和mal1缺陷的小鼠研究了脂肪组织中的代谢改变是怎样通过脂质信号同整个机体代谢联系起来的。
A robust increase in de novo lipogenesis rendered the adipose tissue of these mice resistant to the deleterious effects of dietary lipid exposure.
这些小鼠脂肪组织内脂质从头合成的明显增加使得它们对于饮食脂质暴露的不利影响具有抵抗能力。
Systemic lipid profiling also led to identification of C16:1n7-palmitoleate as an adipose tissue-derived lipid hormone that strongly stimulates muscle insulin action and suppresses hepatosteatosis.
系统脂质分析也使我们将C16:1n7-palmitoleate确认为由脂肪组织分离的脂质荷尔蒙，这种脂质荷尔蒙强烈刺激肌肉中胰岛素的作用，并抑制肝脏脂肪变。
Our data reveal a lipid-mediated endocrine network and demonstrate that adipose tissue uses lipokines such as C16:1n7-palmitoleate to communicate with distant organs and regulate systemic metabolic homeostasis.
我们的数据揭示了一个由脂质介导的内分泌网络，并证明了脂肪组织利用脂肪因子如C16:1n7-palmitoleate来与远距离器官联系并调节系统代谢平衡。
编译：
摘要
个体组织中的脂代谢紊乱会导致胰岛素作用和糖代谢系统破坏。我们利用脂类定量分析和脂肪组织中脂质蛋白伴随蛋白aP2和mal1缺陷的小鼠研究了脂肪组织中的代谢改变是怎样通过脂质信号同整个机体代谢联系起来的。这些小鼠脂肪组织内脂质从头合成的明显增加使得它们对于饮食脂质暴露的不利影响具有抵抗能力。系统脂质分析也使我们将C16:1n7-palmitoleate确认为由脂肪组织分离的脂质荷尔蒙，这种脂质荷尔蒙强烈刺激肌肉中胰岛素的作用，并抑制肝脏脂肪变。我们的数据揭示了一个由脂质介导的内分泌网络，并证明了脂肪组织利用脂肪因子如C16:1n7-palmitoleate来与远距离器官联系并调节系统代谢平衡。
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作者:admin@医学,生命科学 2011-04-01 17:11
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