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【medical-news】遗传学是发生早产儿视网膜病的关
Genetics a key factor in premature infants' devastating eye disease
Genetics play a major role in predisposing infants to retinopathy of prematurity (ROP), a disease prevalent in premature infants that disrupts normal blood vessel development of the retina and can lead to blindness, researchers at Yale School of Medicine report in the November issue of Pediatrics.
揟his is the first definitive study to show that genetic factors are a significant component of ROP, and to quantify the extent of that genetic contribution,?said lead author Vineet Bhandari, M.D., assistant professor of pediatrics at Yale School of Medicine.
ROP is most prevalent and severe in extremely low birth weight newborns with an overall incidence estimated to be as high as 68 percent among those born at less than 1,251 grams (2.75 pounds), and 93 percent in those born less than 750 grams (1.6 pounds). Despite early detection and intervention, ROP may lead to retinal detachment and blindness. In an attempt to treat ROP, researchers have sought significant factors, such as too much oxygen, that contribute to the disease. The Yale team hypothesized that there was a strong genetic connection involved in developing ROP.
They looked at contributing factors and outcomes for ROP within 200 twin pairs born at 32 weeks gestation or less. Study participants were from Yale, the Karolinska Institute in Sweden and the University of Connecticut. These 200 twin pairs had a mean gestational age and birth weight of 29 weeks and 1,332 grams (2.9 pounds), respectively.
揙ur analyses showed that gestational age and duration of supplemental oxygen were the significant independent contributing factors for ROP,?said Bhandari. 揙nce significant non-genetic co-factors for ROP were identified, we calculated the genetic susceptibility and determined that 70 percent of the contribution to ROP was the result of genetic factors alone.?/p>
揟he magnitude to which genetic factors contribute to this major cause of infant morbidity accentuates the need for a shift in the paradigm utilized to identify and treat this disease process,?Bhandari added. 揑t is possible that a dual therapy for ROP aimed at limiting potential environmental risk factors and identifying and targeting specific genetic factors may become the model for future intervention.?/p> 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Genetics a key factor in premature infants' devastating eye disease
遗传因素在早产儿破坏性眼病的发病中起到关键作用
Genetics play a major role in predisposing infants to retinopathy of prematurity (ROP), a disease prevalent in premature infants that disrupts normal blood vessel development of the retina and can lead to blindness, researchers at Yale School of Medicine report in the November issue of Pediatrics.
遗传因素在促发婴幼儿早产儿视网膜病(ROP)发病过程中起到关键作用。ROP是一种多见与早产儿的疾病，这种疾病打断了正常的视网膜血管的发育，可以引起失明。耶鲁大学医学院的研究人员在11月发行的新一期儿科学杂志上报道了这一发现。
“This is the first definitive study to show that genetic factors are a significant component of ROP, and to quantify the extent of that genetic contribution,” said lead author Vineet Bhandari, M.D., assistant professor of pediatrics at Yale School of Medicine.
“这次研究首次明确显示遗传因素是引起ROP发病的重要病因，而且确定了遗传因素对ROP发病的影响程度。”该项研究的创始人，耶鲁大学医学院儿科学副教授Vineet Bhandari博士说。
ROP is most prevalent and severe in extremely low birth weight newborns with an overall incidence estimated to be as high as 68 percent among those born at less than 1,251 grams (2.75 pounds), and 93 percent in those born less than 750 grams (1.6 pounds). Despite early detection and intervention, ROP may lead to retinal detachment and blindness. In an attempt to treat ROP, researchers have sought significant factors, such as too much oxygen, that contribute to the disease. The Yale team hypothesized that there was a strong genetic connection involved in developing ROP.
ROP在极低出生体重儿中发病率相当高，而且病情严重，总发病率在那些出生时体重小于1,251克的新生儿估计高达68％，而出生时体重小于750克的新生儿ROP发病率为93％。尽管临床上对该病能够早期发现和进行干预，但是ROP仍可能导致视网膜剥离和失明。为了尝试治疗ROP,研究人员已经找到重要的致病因素，诸如氧负荷过重等。耶鲁的研究小组猜测存在强烈的遗传因素参与了ROP发病过程。
They looked at contributing factors and outcomes for ROP within 200 twin pairs born at 32 weeks gestation or less. Study participants were from Yale, the Karolinska Institute in Sweden and the University of Connecticut. These 200 twin pairs had a mean gestational age and birth weight of 29 weeks and 1,332 grams (2.9 pounds), respectively.
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作者:admin@医学,生命科学 2011-06-15 05:18
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