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【科普】解析有益胆固醇之作用机理
What Makes Good Cholesterol So "Good" For Us?
Article Date: 07 Mar 2007 - 6:00 PST
High levels of good cholesterol (high density lipoprotein (HDL)) are associated with protection from cardiovascular disease, which remains the leading cause of death in the United States. But what exactly makes HDL so "good" for us?
In an attempt to answer this question researchers from the University of Washington, Seattle, have determined exactly what proteins are contained within HDL and have identified a number of surprises; further analysis of which might provide new understanding of the mechanisms by which HDL provides protection from cardiovascular disease and lead to the development of both accurate indicators of disease risk and new treatments for this disease.
In the study, which appears in the March issue of the Journal of Clinical Investigation, Jay Heinecke and colleagues isolated HDL from both healthy individuals and individuals with coronary artery disease (CAD) and assessed the protein content of these large complexes by mass spectrometry. As well as the expected proteins involved in lipid metabolism, HDL from healthy individuals contained several proteins involved in the innate immune response (including complement proteins), several serine proteinase inhibitors, and many acute-phase inflammatory proteins. By contrast, HDL from patients with CAD contained high levels of the protein apoE, which is involved in lipoprotein transport. As discussed in the accompanying commentary by Muredach Reilly and Alan Tall, this study supports "the concept that HDL plays a role in innate immunity and in the regulation of proteolytic cascades involved in inflammatory and coagulation processes." and "could eventually help in the development of biomarkers to predict the outcome of interventions that alter HDL levels and functions." 本人认领此文。如在48小时内未能提交译文，其他战友可自由认领。 【科普】解析有益胆固醇之作用机理
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What Makes Good Cholesterol So "Good" For Us?
解析有益胆固醇之作用机理
Article Date: 07 Mar 2007 - 6:00 PST
2007年3月7日 太平洋标准时间6时
High levels of good cholesterol (high density lipoprotein (HDL)) are associated with protection from cardiovascular disease, which remains the leading cause of death in the United States. But what exactly makes HDL so "good" for us?
心血管疾病在美国仍然是最主要的死因，高水平的有益胆固醇（高密度脂蛋白 HDL）与防止心血管疾病发生有关联。但是它是如何对人体发挥有益作用的呢？
In an attempt to answer this question researchers from the University of Washington, Seattle, have determined exactly what proteins are contained within HDL and have identified a number of surprises; further analysis of which might provide new understanding of the mechanisms by which HDL provides protection from cardiovascular disease and lead to the development of both accurate indicators of disease risk and new treatments for this disease.
来自美国西雅图华盛顿大学的一项研究试图探究此问题，研究人员已经明确了HDL中包含的蛋白质，并且已经取得了许多令人惊奇的结果；进一步的分析将会阐释其预防心血管疾病的机制，并且HDL可以成为预测心血管疾病风险的指示器以及产生该类疾病新的治疗方法。
In the study, which appears in the March issue of the Journal of Clinical Investigation, Jay Heinecke and colleagues isolated HDL from both healthy individuals and individuals with coronary artery disease (CAD) and assessed the protein content of these large complexes by mass spectrometry. As well as the expected proteins involved in lipid metabolism, HDL from healthy individuals contained several proteins involved in the innate immune response (including complement proteins), several serine proteinase inhibitors, and many acute-phase inflammatory proteins. By contrast, HDL from patients with CAD contained high levels of the protein apoE, which is involved in lipoprotein transport. As discussed in the accompanying commentary by Muredach Reilly and Alan Tall, this study supports "the concept that HDL plays a role in innate immunity and in the regulation of proteolytic cascades involved in inflammatory and coagulation processes." and "could eventually help in the development of biomarkers to predict the outcome of interventions that alter HDL levels and functions."
该研究发表在3月的《临床研究》杂志上，Jay Heinecke和他的同事从大量健康人群和冠心病患者标本中分离出HDL，并用质谱分析测定其HDL含量。也正如预期的那样，健康人群的HDL中包含有几种与人类天然免疫反应有关的蛋白质（包括补体蛋白），几种丝氨酸蛋白酶抑制剂，还有大量急性炎性期的蛋白。而来自冠心病患者的HDL含有高水平的与脂蛋白转运有关的蛋白质apoE。Muredach Reilly and Alan Tall解释说：“该项研究支持HDL参与炎症反应和血液凝固有关的先天免疫反应和蛋白质水解级联反应”；他们还说：“可以最终受益于发展成为预测预后的生物学标记，并且可以通过改善HDL水平和功能而干预疾病结果。” 编译
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作者:admin@医学,生命科学 2011-06-09 16:03
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