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【文摘发布】对社会灾难事件的适应性与卒中发
From the EPIC-Norfolk Prospective Cohort Study.
Author： Surtees PG, Wainwright NW, Luben RL, Wareham NJ, Bingham SA, Khaw KT.
Resource: Stroke. 2007 Mar 15; [Epub ahead of print]
Abstract： BACKGROUND AND PURPOSE: Laboratory-based studies have suggested that individual differences in cardiovascular reactivity and stress adaptive capacity are
associated with stroke incidence. We test the hypothesis that sense of coherence
(SOC), a marker of social stress adaptive capacity, is associated with incident
stroke in a population-based prospective cohort study. METHODS: A total of 20
629 participants, aged 41 to 80 years, in the UK European Prospective
Investigation into Cancer (EPIC)-Norfolk study, who had not previously
experienced a stroke, completed assessments that included SOC and details of
their experience of life events during adulthood. An index of adaptation was
constructed from responses to questions concerning over 80 000 adverse life
events. RESULTS: During 145 000 person-years of follow-up (mean 7.1 years), 452
participants experienced either a fatal or nonfatal stroke event. A strong (as
opposed to a weak) SOC was associated with a reduced rate of stroke incidence
(rate ratio 0.76; 95% CI, 0.60 to 0.96) after adjustment for age, sex,
pre-existing myocardial infarction, diabetes, hypertension treatment, family
history of stroke, cigarette smoking, systolic blood pressure, obesity, social
class, education, hostility and depression. No sex difference in this
association was observed. Measures of social adversity occurrence and impact
were not associated with stroke incidence, whereas faster reported adaptation to
adverse event exposure was associated with a reduced rate of stroke incidence
(rate ratio 0.89; 95% CI, 0.81 to 0.98; per standard deviation change in
adaptation score, adjusted for age and sex). CONCLUSIONS: Stress adaptive
capacity is a potentially important candidate risk factor for stroke.
PMID: 17363725 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Title： Adaptation to Social Adversity Is Associated With Stroke Incidence. Evidence
From the EPIC-Norfolk Prospective Cohort Study.
题目：人们对社会灾难的适应性与中风发病率相关，来自EPIC-Norfolk的前瞻性队列研究。[标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-05-29 05:11
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