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【medical-news】他汀类药物可治疗COPD患者的潜在心
24 January 2007
Treatment with statins may improve survival of patients with the respiratory disorder chronic obstructive pulmonary disease (COPD) because they have unrecognized underlying ischemic heart disease (IHD), Norwegian researchers report.
Their findings showed that mortality was relatively 43% lower in patients after they suffered an acute worsening of their respiratory condition if they were taking statins than if they were not.
According to Vidar Søyseth (Akershus University Hospital) and colleagues, many COPD patients may have subclinical IHD because their dyspnea and chest pain can be interpreted as COPD-related. IHD among COPD patients may persist undiagnosed, even though cardiovascular disease is increasingly recognized as a leading cause of COPD, they say.
In light of this, the researchers hypothesized that statins may reduce mortality in COPD patients.
To test their hypothesis, the scientists retrospectively studied the outcomes of 854 patients who had suffered a COPD exacerbation episode.
Over a median follow-up period of 1.9 years, 333 patients died, the researchers report in the European Respiratory Journal.
After adjusting for gender, age, smoking, pulmonary function, and comorbidities, the hazard ratio (HR) for death among statin users versus non-users was 0.57.
Dividing the statin users and non-users according to concomitant treatment with inhaled corticosteroids (ICS) those receiving statins only had a lower mortality than those on ICS alone, while those receiving both statins and ICS had the lowest mortality.
Concomitant treatment with angiotensin converting enzyme inhibitors, angiotensin receptor blockers, aspirin, beta blockers, or warfarin did not affect mortality risks, however.
The researchers note that 30% of the patients had diagnosed IHD, but that it is likely that many had unrecognized IHD based on autopsy studies and other observational studies.
"In conclusion, the present study shows that use of statins is associated with improved survival after COPD exacerbation, regardless of whether or not the patients have a diagnosis of IHD," the authors write.
Eur Respir J 2007; 29: 279-283
http://www.incirculation.net/NewsItem/Statins-may-treat-underlying-heart-disease-in-resp.aspx 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Statins may treat underlying heart disease in respiratory patients
他汀类药物可治疗COPD患者的潜在性心脏病
2007 .1. 24
Treatment with statins may improve survival of patients with the respiratory disorder chronic obstructive pulmonary disease (COPD) because they have unrecognized underlying ischemic heart disease (IHD), Norwegian researchers report.
挪威的研究人员报道：应用他汀类药物可以改善呼吸系统疾病COPD患者的生存率，因为这类患者并发有局部缺血性的心脏病
Their findings showed that mortality was relatively 43% lower in patients after they suffered an acute worsening of their respiratory condition if they were taking statins than if they were not.
他们的研究结果表明：这类患者在遭受呼吸状况急性恶化后服用他汀类药物患者的死亡率比未服用者相对低43个百分点。
According to Vidar Søyseth (Akershus University Hospital) and colleagues, many COPD patients may have subclinical IHD because their dyspnea and chest pain can be interpreted as COPD-related. IHD among COPD patients may persist undiagnosed, even though cardiovascular disease is increasingly recognized as a leading cause of COPD, they say.
据Vidar Søyseth及其同事指出，许多COPD患者可能合并存在亚临床的局部缺血性的心脏病，原因是COPD患者的呼吸困难及胸部疼痛可以被草率地解释为COPD的相关症状。即便是作为COPD发病首要因素的心血管疾病正在逐渐地认可，COPD患者中的IHD的诊断仍将持续存在漏诊的可能。
In light of this, the researchers hypothesized that statins may reduce mortality in COPD patients.
据此，研究人员设想他汀类药物或许能减低COPD患者的死亡率。
To test their hypothesis, the scientists retrospectively studied the outcomes of 854 patients who had suffered a COPD exacerbation episode.
为了验证他们的设想，科学家们回顾性地研究了854名曾遭受COPD恶化事件患者的结果。
Over a median follow-up period of 1.9 years, 333 patients died, the researchers report in the European Respiratory Journal.
研究人员在欧洲呼吸杂志上报道说，经过中位数时间为1.9年的随访后，有333名患者死亡。
After adjusting for gender, age, smoking, pulmonary function, and comorbidities, the hazard ratio (HR) for death among statin users versus non-users was 0.57.
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作者:admin@医学,生命科学 2011-02-24 17:12
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