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【medical-news】妇科癌症幸存者常见下肢淋巴水肿
http://www.medscape.com/viewarticle/558932
NEW YORK (Reuters Health) Jun 27 - A significant proportion of gynecological cancer survivors develop lower limb lymphedema, according to results of a study published in the June 15th issue of Cancer.
"Lower limb lymphedema is one of the most disabling side effects of surgical and radiotherapy treatment for gynecological cancer," note Dr. Vanessa Beesley, of the Queensland Institute of Medical Research, Australia, and colleagues. "For many gynecological cancer patients, lymph node dissection is an integral part of cancer treatment and surgical staging, and this procedure has been associated with lymphedema development."
The researchers conducted a population-based cross-sectional mail survey of gynecological cancer survivors in 2004. The questionnaire, which was completed by 802 women, included items on demographics, supportive care needs, and lymphedema-related needs.
Overall, 10% of subjects reported a diagnosis of lymphedema. Another 15% reported undiagnosed symptomatic lower leg swelling. The prevalence of diagnosed lymphedema was higher among survivors of vulvar cancer (36%) than all other gynecological cancer subgroups.
Multivariate analysis revealed that for cervical cancer survivors, the odds of developing lower limb swelling were 3.5 times higher if they had radiotherapy and 3.3 times higher if they had lymph nodes removed. The odds of developing lymphedema were higher for survivors of uterine and ovarian cancer who had lymph node dissection or who were overweight or obese.
"Whereas 31% reported being informed about lymphedema before their cancer treatment, 34% of women did not recall being informed about this condition until they were diagnosed," Dr. Beesley and colleagues report. "Others (30%) were informed after their cancer treatment but before symptoms arose, or they could not remember when they were informed (5%)."
The researchers note that supportive care needs in the information and symptom management domains were higher in gynecological cancer survivors with lymphedema than in those with no swelling.
"Women at risk for lymphedema would benefit from instructions about early signs and symptoms and provision of referral information," the team concludes.
Cancer 2007;109:2607-2614. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Lower Limb Lymphedema Common in Survivors of Gynecological Cancer
妇科癌症幸存者常见下肢淋巴水肿
http://www.medscape.com/viewarticle/558932
NEW YORK (Reuters Health) Jun 27 - A significant proportion of gynecological cancer survivors develop lower limb lymphedema, according to results of a study published in the June 15th issue of Cancer.
纽约（路透社健康新闻）6月27日消息—据发表于6月15日《癌症》杂志上的一项研究结果，相当一部分妇科癌症患者患有下肢淋巴水肿。
"Lower limb lymphedema is one of the most disabling side effects of surgical and radiotherapy treatment for gynecological cancer," note Dr. Vanessa Beesley, of the Queensland Institute of Medical Research, Australia, and colleagues. "For many gynecological cancer patients, lymph node dissection is an integral part of cancer treatment and surgical staging, and this procedure has been associated with lymphedema development."
“下肢淋巴水肿是妇科癌症患者接受手术治疗和放疗后最易致残的一项副作用。”澳大利亚昆士兰医学研究所的Vanessa Beesley医生及其同事说。“对许多妇科癌症患者来说，淋巴结切除术是整个抗癌治疗计划的一部分，有助于了解疾病的临床分期，该手术往往会导致淋巴水肿。”
The researchers conducted a population-based cross-sectional mail survey of gynecological cancer survivors in 2004. The questionnaire, which was completed by 802 women, included items on demographics, supportive care needs, and lymphedema-related needs.
研究者们在2004年以邮寄信件的方式针对妇科癌症患者开展了一项基于人群的横断面调查。共有802名女性填写了调查问卷，内容包括人口统计学资料、支持护理需求和与淋巴水肿相关的一些需求。
Overall, 10% of subjects reported a diagnosis of lymphedema. Another 15% reported undiagnosed symptomatic lower leg swelling. The prevalence of diagnosed lymphedema was higher among survivors of vulvar cancer (36%) than all other gynecological cancer subgroups.
总体上，共有10%的被调查者报告被诊断为淋巴水肿。还有15%的被调查者报告有未知原因的症状性下肢肿胀。在患外阴癌的病人中，被诊断为淋巴水肿的病人比例（36%）高于患其他妇科癌症的病人。
Multivariate analysis revealed that for cervical cancer survivors, the odds of developing lower limb swelling were 3.5 times higher if they had radiotherapy and 3.3 times higher if they had lymph nodes removed. The odds of developing lymphedema were higher for survivors of uterine and ovarian cancer who had lymph node dissection or who were overweight or obese.
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作者:admin@医学,生命科学 2011-02-24 17:11
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