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【medical-news】父方年龄在生育中同样重要
Drop in Pregnancy Rates After Fertility Treatments When Men Are Over 40
A woman's age plays a key role in her ability to get pregnant, but a landmark study now shows that dad's age may be just as important.
A study of more than 12,000 couples undergoing fertility treatments has found that pregnancy rates drop and miscarriages increase when the father is older than 40. The findings are being presented today at the 24th annual conference of the European Society of Human Reproduction and Embryology in Barcelona, Spain.
The results are believed to be the first to show that simply being an older dad has a strong effect on reproductive outcomes.
Researcher Stephanie Belloc of the Eylau Centre for Assisted Reproduction in Paris and colleagues analyzed the outcomes of more than 21,000 intrauterine inseminations (IUIs). An IUI is a type of fertility treatment in which the man's sperm is first separated (or "washed") from the seminal fluid and then inserted into the woman's uterus. The team looked at sperm quality and pregnancy, miscarriage, and delivery rates.
"We found that the age of the father was important in pregnancy rates -- men over 40 had a negative effect," Belloc says in a news release. "And, perhaps, more surprisingly, miscarriages rates increased where the father was over 40."
How a father's age influences fertility has been a matter of debate. Until now, there's been no clinical proof that simply being an older dad directly affects a couple's ability to conceive and achieve a healthy pregnancy.
"Our research proves for the first time that there is a strong paternal age-related effect on IUI outcomes, and this information should be considered by both doctors and patients in assisted reproduction programs," Belloc says.
Even though the trial involved a large number of couples, Belloc plans further studies to confirm the results. "This research has important implications for couples wanting to start a family," she says, "and we need to research it in as large a group as possible."
Belloc recommends that fertility specialists suggest in vitro fertilization [IVF] or intracytoplasmic sperm injection (ICSI) -- a technique that places sperm directly into an egg -- to couples when either partner is over age 40.
"These methods, although not in themselves a guarantee of success, may help couples where the man is older to achieve a pregnancy more quickly, and also reduce the risk of miscarriage," she says.
Belloc's results also confirmed that women over 35 have lower pregnancy rates than younger woman, and are more likely to miscarry.
新闻来源：http://www.webmd.com/infertility-and-reproduction/news/20080707/dads-age-plays-role-in-fertility Dad's Age Plays Role in Fertility
爸爸的年龄在生育中同样重要
Drop in Pregnancy Rates After Fertility Treatments When Men Are Over 40
男性超过40岁时，生育治疗的受孕率下降
A woman's age plays a key role in her ability to get pregnant, but a landmark study now shows that dad's age may be just as important.
女人的年龄在受孕能力上扮演很重要的角色，但是一个里程碑的研究表明，爸爸的年龄也同样重要。
A study of more than 12,000 couples undergoing fertility treatments has found that pregnancy rates drop and miscarriages increase when the father is older than 40. The findings are being presented today at the 24th annual conference of the European Society of Human Reproduction and Embryology in Barcelona, Spain.
对12，000对经历受孕治疗的夫妻的研究表明，如果爸爸的年龄大于40岁，受孕率下降且流产的增多，这个发现于今天在西班牙巴塞罗那的欧洲人类生殖与胚胎学协会第24次年度会议上提交。
The results are believed to be the first to show that simply being an older dad has a strong effect on reproductive outcomes.
这个结果被认为是第一次表明了仅仅因为做老爸爸会很强的影响生殖的结果。
Researcher Stephanie Belloc of the Eylau Centre for Assisted Reproduction in Paris and colleagues analyzed the outcomes of more than 21,000 intrauterine inseminations (IUIs). An IUI is a type of fertility treatment in which the man's sperm is first separated (or "washed") from the seminal fluid and then inserted into the woman's uterus. The team looked at sperm quality and pregnancy, miscarriage, and delivery rates.
巴黎旨在辅助生殖的Eylau中心的研究者Stephanie Belloc分析了21，000以上宫内受精(IUIs)的结果，IUI是一种生育治疗的方式，通过这种方式，男人的精子从精液中分离，（或者“洗涤”）注入女人的子宫，该小组研究精子质量、妊娠、流产和分娩率。
"We found that the age of the father was important in pregnancy rates -- men over 40 had a negative effect," Belloc says in a news release. "And, perhaps, more surprisingly, miscarriages rates increased where the father was over 40."
“我们发现父亲的年龄对妊娠率来说很重要，男人年龄超过40岁会产生消极的影响”，Belloc在新闻发布会上说。“也许，更令人惊讶的是父亲年龄超过40岁流产率会上升。”
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作者:admin@医学,生命科学 2011-08-14 17:15
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