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【JCEM】ATD控制良好的甲亢患者妊娠后对复发的影
http://jcem.endojournals.org/cgi/content/abstract/jc.2008-0966v1?papetoc
Objective: Pregnancy and the post-partum (PP) period are associated with profound changes of the immune system, which largely influence the clinical activity of autoimmune diseases.
Aim of this study was to evaluate the effect of pregnancy and/or of the PP period in driving a clinical relapse of hyperthyroidism in patients with Graves' disease (GD) who are in remission after anti-thyroid drug (ATD) treatment. Data were retrospectively collected from 150 female patients with GD, who were assigned to two groups according to the occurrence of a successful pregnancy after ATD withdrawal.
Results: Relapsing Graves' hyperthyroidism was observed in 70/125 (56.0%) patients in Group I (no pregnancy after ATD withdrawal) and in 21/25 (84.0%) patients in Group II (pregnancy after ATD withdrawal) (p<0.05). Logistic regression analysis (dependent variable: relapse/non relapse; covariates: age, positive family history for autoimmune thyroid disease, duration of treatment with ATD, number pregnancies at diagnosis, number of pregnancies following ATD withdrawal), showed a significant effect only for the number of pregnancies following ATD withdrawal [4.257 (1.315–13.782)]. The effect was ascribed to the PP period rather than to pregnancy itself, because in 20/21 (95.2%) patients of Group II, the relapse of Graves' hyperthyroidism occurred between 4 and 8 months after delivery.
Conclusions: The PP period is significantly associated with a relapse of hyperthyroidism in GD patients being in remission after ATD. We therefore recommend that patients with GD in remission after a course of ATD should have their thyroid function tested at 3 and 6 months after delivery. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 The effect of pregnancy on subsequent relapse from Graves' disease following a successful course of anti-thyroid drug therapy
ATD控制良好的Graves病患者妊娠后对复发的影响
http://jcem.endojournals.org/cgi/content/abstract/jc.2008-0966v1?papetoc
Objective: Pregnancy and the post-partum (PP) period are associated with profound changes of the immune system, which largely influence the clinical activity of autoimmune diseases.
目的：怀孕和产后（PP）阶段免疫系统会发生深刻的变化，这对自身免疫病的临床活动影响很大。
Aim of this study was to evaluate the effect of pregnancy and/or of the PP period in driving a clinical relapse of hyperthyroidism in patients with Graves' disease (GD) who are in remission after anti-thyroid drug (ATD) treatment. Data were retrospectively collected from 150 female patients with GD, who were assigned to two groups according to the occurrence of a successful pregnancy after ATD withdrawal.
这个研究的目的是评价通过抗甲亢药物（ATD）治疗缓解的Graves病患者(GD)怀孕和/或产后阶段对甲亢复发的影响。数据收集来自150名女性GD患者，按照ATD撤药后成功怀孕的发生分为两组。
Results: Relapsing Graves' hyperthyroidism was observed in 70/125 (56.0%) patients in Group I (no pregnancy after ATD withdrawal) and in 21/25 (84.0%) patients in Group II (pregnancy after ATD withdrawal) (p<0.05). Logistic regression analysis (dependent variable: relapse/non relapse; covariates: age, positive family history for autoimmune thyroid disease, duration of treatment with ATD, number pregnancies at diagnosis, number of pregnancies following ATD withdrawal), showed a significant effect only for the number of pregnancies following ATD withdrawal [4.257 (1.315–13.782)]. The effect was ascribed to the PP period rather than to pregnancy itself, because in 20/21 (95.2%) patients of Group II, the relapse of Graves' hyperthyroidism occurred between 4 and 8 months after delivery.
结果：，一组（ATD撤药后没有怀孕）70/125 (56.0%)的患者被观察到甲亢复发，二组（ATD撤药后怀孕）为21/25 (84.0%)(p<0.05)。对数回归分析（从属变量：复发/未复发；相关变量：年龄，自身免疫甲状腺疾病家族史阳性，ATD治疗的时间，诊断的怀孕次数，ATD撤药后的怀孕次数），显示只有ATD撤药后的怀孕次数有重要影响[4.257 (1.315–13.782)]。这影响主要是由于PP阶段而不是怀孕本身，因为20/21 (95.2%)的二组患者甲亢复发与分娩后的4到8个月。
Conclusions: The PP period is significantly associated with a relapse of hyperthyroidism in GD patients being in remission after ATD. We therefore recommend that patients with GD in remission after a course of ATD should have their thyroid function tested at 3 and 6 months after delivery.
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作者:admin@医学,生命科学 2011-06-27 17:47
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