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【medical-news】不育妇女乳腺癌及卵巢癌风险增加
"One of the most well-established risk factors for breast, ovarian, and endometrial cancer is parity: Nulliparous women have an increased risk in comparison with parous women," Dr. Allan Jensen and colleagues from the Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, write. "A diagnosis of infertility and infertility treatment are related factors also considered to influence risk of these cancers."
The researchers linked data from a large cohort of 54,362 women referred to Danish fertility clinics with information in the Danish Cancer Registry. Using general and parity-specific cancer incidence rates in the general Danish population as a reference, the team assessed cancer risk through standardized incidence ratios (SIRs).
The median length of follow-up was 13 years. Significantly increased SIRs were found for breast and ovarian cancer after adjustment for parity status (SIRs = 1.08 and 1.46, respectively). The risk of breast cancer increased with increasing length of follow-up.
"The increased risk of breast cancer and ovarian cancer after adjustment for parity indicates that other infertility related factors may have the potential to increase the risk of these cancers," Dr. Jensen pointed out in comments to Reuters Health. "Two likely candidates are a shared genetic/biological susceptibility to both cancer and infertility and/or use of fertility drugs."
"Further within-cohort studies are in progress to disentangle the effects of underlying infertility and infertility treatment on cancer risk," the researcher explained. "Furthermore, as our results primarily are based on cancers occurring at a relatively early age, additional follow-up studies are needed to further explore the long-term risk of breast cancer and ovarian cancer among infertile women."
Am J Epidemiol 2008;168:49-57. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 NEW YORK (Reuters Health) Jul 29 - Infertile women have an increased risk of breast and ovarian cancer, although the risk could be related to fertility treatment rather than infertility per se, according to a Danish study published in the July issue of the American Journal of Epidemiology.
（路透社卫生）纽约7月29日－美国流行病学杂志7月刊登了一篇来自丹麦的研究报告，报告称：不育妇女患乳腺癌和卵巢癌的风险增高，风险可能并非源于不育症本身，而是来自于对不育症的治疗。
"One of the most well-established risk factors for breast, ovarian, and endometrial cancer is parity: Nulliparous women have an increased risk in comparison with parous women," Dr. Allan Jensen and colleagues from the Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, write. "A diagnosis of infertility and infertility treatment are related factors also considered to influence risk of these cancers."
来自位于于哥本哈根的丹麦癌症学会癌症流行病研究所的Allan Jensen医生及其同事称，产次是公认的乳腺癌、卵巢癌、子宫内膜癌发病的的影响因素之一，而且未经产妇女患癌的风险高于经产妇女。不育症的诊断和治疗作为相关因素也被认为对上述癌症的发病风险有影响。
The researchers linked data from a large cohort of 54,362 women referred to Danish fertility clinics with information in the Danish Cancer Registry. Using general and parity-specific cancer incidence rates in the general Danish population as a reference, the team assessed cancer risk through standardized incidence ratios (SIRs).
研究人员搜集了54,362名在丹麦癌症登记局注册的丹麦生育诊所就诊的妇女的资料。用在丹麦总人口中总的和孩次别癌症发生率作为参数，用标准化发生率(SIRs)对癌症风险进行了评估。
The median length of follow-up was 13 years. Significantly increased SIRs were found for breast and ovarian cancer after adjustment for parity status (SIRs = 1.08 and 1.46, respectively). The risk of breast cancer increased with increasing length of follow-up.
中位随访时间为13年。在调整产次后，乳腺癌和卵巢癌的标准化发生率显著增高，分别为1.08和1.46。而且患乳腺癌的风险随着随访时间的增长而增加。
"The increased risk of breast cancer and ovarian cancer after adjustment for parity indicates that other infertility related factors may have the potential to increase the risk of these cancers," Dr. Jensen pointed out in comments to Reuters Health. "Two likely candidates are a shared genetic/biological susceptibility to both cancer and infertility and/or use of fertility drugs."
Jensen医生在给路透社卫生的注解中说：“调整产次后乳腺癌和卵巢癌的标准化发生率增高表明不育的其他相关因素可能潜在增加了患上述癌症的风险。其中两个可能因素：不育与癌症共享的遗传生物敏感性和（或）生育药的使用。”
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作者:admin@医学,生命科学 2011-05-24 05:14
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