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【Blood】异基因干细胞动员效果在人种上的区别
A reliable estimate of peripheral blood stem cell (PBSC) mobilization response to granulocyte colony-stimulating factor (G-CSF) may identify donors at risk for poor mobilization and help optimize transplantation approaches. We studied 639 allogeneic PBSC collections performed in 412 white, 75 black, 116 Hispanic, and 36 Asian/Pacific adult donors who were prescribed G-CSF dosed at either 10 or 16 µg/kg per day for 5 days followed by large-volume leukapheresis (LVL). Additional LVL (mean, 11 L) to collect lymphocytes for donor lymphocyte infusion (DLI) and other therapies was performed before G-CSF administration in 299 of these donors. Day 5 preapheresis blood CD34+ cell counts after mobilization were significantly lower in whites compared with blacks, Hispanics, and Asian/Pacific donors (79 vs 104, 94, and 101 cells/µL, P < .001). In addition, donors who underwent lymphapheresis before mobilization had higher CD34+ cell counts than donors who did not (94 vs 79 cells/µL, P < .001). In multivariate analysis, higher post–G-CSF CD34+ cell counts were most strongly associated with the total amount of G-CSF received, followed by the pre–G-CSF platelet count, pre–G-CSF mononuclear count, and performance of prior LVL for DLI collection. Age, white ethnicity, and female gender were associated with significantly lower post–G-CSF CD34+ cell counts. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Donor demographic and laboratory predictors of allogeneic peripheral blood stem cell mobilization in an ethnically diverse population
在不同族裔人群中，供者异基因外周血干细胞动员效果的的人口统计及实验室的预测因子
A reliable estimate of peripheral blood stem cell (PBSC) mobilization response to granulocyte colony-stimulating factor (G-CSF) may identify donors at risk for poor mobilization and help optimize transplantation approaches.
对于接受粒细胞集落刺激因子刺激的的外周血造血干细胞动员反应程度的可靠估计可以用来确定供者有否的较差的外周血动员并进而帮助优化移植。
We studied 639 allogeneic PBSC collections performed in 412 white, 75 black, 116 Hispanic, and 36 Asian/Pacific adult donors who were prescribed G-CSF dosed at either 10 or 16 µg/kg per day for 5 days followed by large-volume leukapheresis (LVL).
我们研究了639例异基因外周血干细胞收集，412个白人，75个黑人， 116个拉美裔和36亚洲/太平洋成年供者，他们接受了G-CSF动员，剂量在10或者16微克/千克•每天，5天之后又接受大容量白细胞分离术。
Additional LVL (mean, 11 L) to collect lymphocytes for donor lymphocyte infusion (DLI) and other therapies was performed before G-CSF administration in 299 of these donors.
其中299名供者在G-CSF动员前接受附加白细胞分离术（平均，11L），收集供者淋巴细胞用以供者淋巴细胞输注以及其他治疗。
Day 5 preapheresis blood CD34+ cell counts after mobilization were significantly lower in whites compared with blacks, Hispanics, and Asian/Pacific donors (79 vs 104, 94, and 101 cells/µL, P < .001).
动员后第5天收获的血液CD34+细胞计数显示：白人的动员效果显著低于与黑人，拉美和亚洲/太平洋的供者（ 79比104，94，和101个细胞/ μL ，P<.001 ）。
In addition, donors who underwent lymphapheresis before mobilization had higher CD34+ cell counts than donors who did not (94 vs 79 cells/µL, P < .001).
此外，同动员前未接受淋巴细胞清除的供者比，动员前接受淋巴细胞清除的的供者有较高的CD34+细胞计数（ 94比79细胞/ μL ，P<.001）。
In multivariate analysis, higher post–G-CSF CD34+ cell counts were most strongly associated with the total amount of G-CSF received, followed by the pre–G-CSF platelet count, pre–G-CSF mononuclear count, and performance of prior LVL for DLI collection.
在多变量分析，更高的G-CSF动员后的CD34+细胞计数最强烈的关联包括：总的G-CSF动员的剂量，其次是G-CSF动员前血小板计数，G-CSF动员前单个核细胞数，以及动员前为供者淋巴细胞输注而接受白细胞分离术。
Age, white ethnicity, and female gender were associated with significantly lower post–G-CSF CD34+ cell counts.
年龄，白色人种，女性 同G-CSF动员后显著降低CD34+细胞计数相关。 编译：
在不同族裔人群中，供者异基因外周血干细胞动员效果的的人口学统计及实验室的预测因子
对于接受粒细胞集落刺激因子刺激的的外周血造血干细胞动员反应程度的可靠估计可以用来确定供者有否的较差的外周血动员并进而帮助优化移植。
我们研究了639例异基因外周血干细胞收集，412个白人，75个黑人， 116个拉美裔和36亚洲/太平洋成年供者，他们接受了G-CSF动员，剂量在10或者16微克/千克•每天，5天之后又接受大容量白细胞分离术。
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作者:admin@医学,生命科学 2011-03-28 05:11
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