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【Nature Immunology 编译】TIM-1与它的配体TIM-4相互作
TIM-4 is the ligand for TIM-1, and the TIM-1−TIM-4 interaction regulates T cell proliferation
来源
Nature Immunology 6, 455 - 464 (2005)
Published online: 27 March 2005; | doi:10.1038/ni1185
http://www.nature.com/ni/journal/v6/n5/abs/ni1185.html
摘要原文
The newly identified TIM family of proteins is associated with regulation of T helper type 1 (TH1) and TH2 immune responses. TIM-1 is genetically linked to asthma and is a receptor for hepatitis A virus, but the endogenous ligand of TIM-1 is not known. Here we show that TIM-4, which is expressed by antigen-presenting cells, is the ligand for TIM-1. In vivo administration of either soluble TIM-1−immunoglobulin (TIM-1−Ig) fusion protein or TIM-4−Ig fusion protein resulted in hyperproliferation of T cells, and TIM-4−Ig costimulated T cell proliferation mediated by CD3 and CD28 in vitro. These data suggest that the TIM-1−TIM-4 interaction is involved in regulating T cell proliferation.
编译
最近确定的TIM家族蛋白与调节TH1辅助细胞和TH2辅助细胞的免疫反应有关。TIM-1蛋白遗传学上与哮喘有关，是甲肝病毒的受体，但它的内源性的配体一直没有发现。我们的研究发现表达在抗原递呈细胞上的TIM-4就是它的配体。在体内给予可溶的TIM-1免疫球蛋白（TIM-1-Ig）融合蛋白或者TIM-4免疫球蛋白（TIM-4-Ig）融合蛋白，都可导致T细胞的过度增殖。在体外TIM-4-Ig通过CD3和CD28来共同刺激T细胞增殖。这些数据表明TIM-1-TIM-4 的相互作用在调节T细胞的增殖过程中起作用。 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-03-27 11:51
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